Remote Effects of Hippocampal Sclerosis on Effective Connectivity during Working Memory Encoding: A Case of Connectional Diaschisis?

Campo, Pablo and Garrido, Marta I. and Moran, Rosalyn and Maestú, Fernando and Garcia Morales, Irene and Gil Nagel, Antonio and Pozo Guerrero, Francisco del and Dolan, Raymond J. and Friston, Karl J. (2011). Remote Effects of Hippocampal Sclerosis on Effective Connectivity during Working Memory Encoding: A Case of Connectional Diaschisis?. "Cerebral Cortex", v. 22 (n. 6); pp. 1225-1236. ISSN 1047-3211. https://doi.org/10.1093/cercor/bhr201.

Description

Title: Remote Effects of Hippocampal Sclerosis on Effective Connectivity during Working Memory Encoding: A Case of Connectional Diaschisis?
Author/s:
  • Campo, Pablo
  • Garrido, Marta I.
  • Moran, Rosalyn
  • Maestú, Fernando
  • Garcia Morales, Irene
  • Gil Nagel, Antonio
  • Pozo Guerrero, Francisco del
  • Dolan, Raymond J.
  • Friston, Karl J.
Item Type: Article
Título de Revista/Publicación: Cerebral Cortex
Date: 2011
ISSN: 1047-3211
Volume: 22
Subjects:
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

[img]
Preview
PDF - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (614kB) | Preview

Abstract

Accumulating evidence suggests a role for the medial temporal lobe (MTL) in working memory (WM). However, little is known concerning its functional interactions with other cortical regions in the distributed neural network subserving WM. To reveal these, we availed of subjects with MTL damage and characterized changes in effective connectivity while subjects engaged in WM task. Specifically, we compared dynamic causal models, extracted from magnetoencephalographic recordings during verbal WM encoding, in temporal lobe epilepsy patients (with left hippocampal sclerosis) and controls. Bayesian model comparison indicated that the best model (across subjects) evidenced bilateral, forward, and backward connections, coupling inferior temporal cortex (ITC), inferior frontal cortex (IFC), and MTL. MTL damage weakened backward connections from left MTL to left ITC, a decrease accompanied by strengthening of (bidirectional) connections between IFC and MTL in the contralesional hemisphere. These findings provide novel evidence concerning functional interactions between nodes of this fundamental cognitive network and sheds light on how these interactions are modified as a result of focal damage to MTL. The findings highlight that a reduced (top-down) influence of the MTL on ipsilateral language regions is accompanied by enhanced reciprocal coupling in the undamaged hemisphere providing a first demonstration of “connectional diaschisis.”

More information

Item ID: 13658
DC Identifier: http://oa.upm.es/13658/
OAI Identifier: oai:oa.upm.es:13658
DOI: 10.1093/cercor/bhr201
Official URL: http://cercor.oxfordjournals.org/content/22/6/1225.long
Deposited by: Memoria Investigacion
Deposited on: 21 Nov 2012 10:17
Last Modified: 21 Apr 2016 12:59
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM