Lempel-Ziv complexity in schizophrenia: A MEG study

Fernandez Perez, Alberto and Lopez Ibor, Maria Ines and Turrero, Agustin and Santos, Juan Matias and Moron, Maria Dolores and Hornero, Roberto and Gomez, Carlos and Andreina Mendez, Maria and Ortiz, Tomas and Lopez Ibor, Juan Jose (2011). Lempel-Ziv complexity in schizophrenia: A MEG study. "Clin Neurophysiology", v. 122 (n. 11); pp. 2227-2235. ISSN 0736-0258.


Title: Lempel-Ziv complexity in schizophrenia: A MEG study
  • Fernandez Perez, Alberto
  • Lopez Ibor, Maria Ines
  • Turrero, Agustin
  • Santos, Juan Matias
  • Moron, Maria Dolores
  • Hornero, Roberto
  • Gomez, Carlos
  • Andreina Mendez, Maria
  • Ortiz, Tomas
  • Lopez Ibor, Juan Jose
Item Type: Article
Título de Revista/Publicación: Clin Neurophysiology
Date: November 2011
Volume: 122
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Official URL: http://dx.doi.org/10.1016/j.clinph.2011.04.011


Objective The neurodevelopmental–neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods Fifteen patients (age range 23–42 years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23–42 years) underwent a resting-state magnetoencephalographic evaluation and Lempel–Ziv complexity (LZC) scores were calculated. Results Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. Conclusions Results demonstrated that SCH patients failed to follow the “normal” process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. Significance Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration. Highlights ► Schizophrenic patients show higher complexity values as compared to controls. ► Schizophrenic patients showed a tendency to reduced complexity values as a function of age while controls showed the opposite tendency. ► The tendency observed in schizophrenic patients parallels the tendency observed in Alzheimer disease patients.

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Item ID: 13661
DC Identifier: http://oa.upm.es/13661/
OAI Identifier: oai:oa.upm.es:13661
Deposited by: Memoria Investigacion
Deposited on: 21 Nov 2012 09:34
Last Modified: 21 Apr 2016 12:59
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