Lempel-Ziv complexity in schizophrenia: A MEG study

Fernandez Perez, Alberto; Lopez Ibor, Maria Ines; Turrero, Agustin; Santos, Juan Matias; Moron, Maria Dolores; Hornero, Roberto; Gomez, Carlos; Andreina Mendez, Maria; Ortiz, Tomas y Lopez Ibor, Juan Jose (2011). Lempel-Ziv complexity in schizophrenia: A MEG study. "Clin Neurophysiology", v. 122 (n. 11); pp. 2227-2235. ISSN 0736-0258. https://doi.org/10.1016/j.clinph.2011.04.011.

Descripción

Título: Lempel-Ziv complexity in schizophrenia: A MEG study
Autor/es:
  • Fernandez Perez, Alberto
  • Lopez Ibor, Maria Ines
  • Turrero, Agustin
  • Santos, Juan Matias
  • Moron, Maria Dolores
  • Hornero, Roberto
  • Gomez, Carlos
  • Andreina Mendez, Maria
  • Ortiz, Tomas
  • Lopez Ibor, Juan Jose
Tipo de Documento: Artículo
Título de Revista/Publicación: Clin Neurophysiology
Fecha: Noviembre 2011
Volumen: 122
Materias:
Escuela: E.T.S.I. Telecomunicación (UPM)
Departamento: Tecnología Fotónica [hasta 2014]
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Objective The neurodevelopmental–neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods Fifteen patients (age range 23–42 years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23–42 years) underwent a resting-state magnetoencephalographic evaluation and Lempel–Ziv complexity (LZC) scores were calculated. Results Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. Conclusions Results demonstrated that SCH patients failed to follow the “normal” process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. Significance Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration. Highlights ► Schizophrenic patients show higher complexity values as compared to controls. ► Schizophrenic patients showed a tendency to reduced complexity values as a function of age while controls showed the opposite tendency. ► The tendency observed in schizophrenic patients parallels the tendency observed in Alzheimer disease patients.

Más información

ID de Registro: 13661
Identificador DC: http://oa.upm.es/13661/
Identificador OAI: oai:oa.upm.es:13661
Identificador DOI: 10.1016/j.clinph.2011.04.011
Depositado por: Memoria Investigacion
Depositado el: 21 Nov 2012 09:34
Ultima Modificación: 21 Abr 2016 12:59
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