Unveiling Protein Functions through the Dynamics of the Interaction Network

Sendiña Nadal, Irene and Ofran, Yanai and Almendral, Juan A. and Buldu, Javier M. and Leyva, Inmaculada and Li, Daqing and Shlomo, Havlin and Boccaletti, Stefano (2011). Unveiling Protein Functions through the Dynamics of the Interaction Network. "Plos One", v. 6 (n. 3); pp.. ISSN 1932-6203. https://doi.org/10.1371/journal.pone.0017679.

Description

Title: Unveiling Protein Functions through the Dynamics of the Interaction Network
Author/s:
  • Sendiña Nadal, Irene
  • Ofran, Yanai
  • Almendral, Juan A.
  • Buldu, Javier M.
  • Leyva, Inmaculada
  • Li, Daqing
  • Shlomo, Havlin
  • Boccaletti, Stefano
Item Type: Article
Título de Revista/Publicación: Plos One
Date: 2011
ISSN: 1932-6203
Volume: 6
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Protein interaction networks have become a tool to study biological processes, either for predicting molecular functions or for designing proper new drugs to regulate the main biological interactions. Furthermore, such networks are known to be organized in sub-networks of proteins contributing to the same cellular function. However, the protein function prediction is not accurate and each protein has traditionally been assigned to only one function by the network formalism. By considering the network of the physical interactions between proteins of the yeast together with a manual and single functional classification scheme, we introduce a method able to reveal important information on protein function, at both micro- and macro-scale. In particular, the inspection of the properties of oscillatory dynamics on top of the protein interaction network leads to the identification of misclassification problems in protein function assignments, as well as to unveil correct identification of protein functions. We also demonstrate that our approach can give a network representation of the meta-organization of biological processes by unraveling the interactions between different functional classes

More information

Item ID: 13664
DC Identifier: http://oa.upm.es/13664/
OAI Identifier: oai:oa.upm.es:13664
DOI: 10.1371/journal.pone.0017679
Official URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017679
Deposited by: Memoria Investigacion
Deposited on: 10 Oct 2012 11:49
Last Modified: 07 Apr 2019 10:33
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