Unveiling Protein Functions through the Dynamics of the Interaction Network

Sendiña Nadal, Irene; Ofran, Yanai; Almendral, Juan A.; Buldu, Javier M.; Leyva, Inmaculada; Li, Daqing; Shlomo, Havlin y Boccaletti, Stefano (2011). Unveiling Protein Functions through the Dynamics of the Interaction Network. "Plos One", v. 6 (n. 3); pp.. ISSN 1932-6203. https://doi.org/10.1371/journal.pone.0017679.

Descripción

Título: Unveiling Protein Functions through the Dynamics of the Interaction Network
Autor/es:
  • Sendiña Nadal, Irene
  • Ofran, Yanai
  • Almendral, Juan A.
  • Buldu, Javier M.
  • Leyva, Inmaculada
  • Li, Daqing
  • Shlomo, Havlin
  • Boccaletti, Stefano
Tipo de Documento: Artículo
Título de Revista/Publicación: Plos One
Fecha: 2011
Volumen: 6
Materias:
Escuela: E.T.S.I. Telecomunicación (UPM)
Departamento: Sistemas Electrónicos y de Control [hasta 2014]
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Protein interaction networks have become a tool to study biological processes, either for predicting molecular functions or for designing proper new drugs to regulate the main biological interactions. Furthermore, such networks are known to be organized in sub-networks of proteins contributing to the same cellular function. However, the protein function prediction is not accurate and each protein has traditionally been assigned to only one function by the network formalism. By considering the network of the physical interactions between proteins of the yeast together with a manual and single functional classification scheme, we introduce a method able to reveal important information on protein function, at both micro- and macro-scale. In particular, the inspection of the properties of oscillatory dynamics on top of the protein interaction network leads to the identification of misclassification problems in protein function assignments, as well as to unveil correct identification of protein functions. We also demonstrate that our approach can give a network representation of the meta-organization of biological processes by unraveling the interactions between different functional classes

Más información

ID de Registro: 13664
Identificador DC: http://oa.upm.es/13664/
Identificador OAI: oai:oa.upm.es:13664
Identificador DOI: 10.1371/journal.pone.0017679
URL Oficial: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017679
Depositado por: Memoria Investigacion
Depositado el: 10 Oct 2012 11:49
Ultima Modificación: 21 Abr 2016 12:59
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