Reduced synchronization persistence in neural networks derived from atm-deficient mice

Levine-Small, Noah and Yekutieli, Ziv and Aljadef, Jonathan and Boccaletti, Stefano and Ben-Jacob, Eshel and Barzilai, Ari (2011). Reduced synchronization persistence in neural networks derived from atm-deficient mice. "Frontiers in Neuroscience" (n. 5); p. 46. ISSN 1662-4548. https://doi.org/10.3389/fnins.2011.00046.

Description

Title: Reduced synchronization persistence in neural networks derived from atm-deficient mice
Author/s:
  • Levine-Small, Noah
  • Yekutieli, Ziv
  • Aljadef, Jonathan
  • Boccaletti, Stefano
  • Ben-Jacob, Eshel
  • Barzilai, Ari
Item Type: Article
Título de Revista/Publicación: Frontiers in Neuroscience
Date: 2011
ISSN: 1662-4548
Subjects:
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Sistemas Electrónicos y de Control [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Many neurodegenerative diseases are characterized by malfunction of the DNA damage response. Therefore, it is important to understand the connection between system level neural network behavior and DNA. Neural networks drawn from genetically engineered animals, interfaced with micro-electrode arrays allowed us to unveil connections between networks’ system level activity properties and such genome instability. We discovered that Atm protein deficiency, which in humans leads to progressive motor impairment, leads to a reduced synchronization persistence compared to wild type synchronization, after chemically imposed DNA damage. Not only do these results suggest a role for DNA stability in neural network activity, they also establish an experimental paradigm for empirically determining the role a gene plays on the behavior of a neural network.

More information

Item ID: 13666
DC Identifier: http://oa.upm.es/13666/
OAI Identifier: oai:oa.upm.es:13666
DOI: 10.3389/fnins.2011.00046
Official URL: http://www.frontiersin.org/Neurodegeneration/10.3389/fnins.2011.00046/abstract
Deposited by: Memoria Investigacion
Deposited on: 10 Oct 2012 11:08
Last Modified: 21 Apr 2016 12:59
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