A stereological study of synapse number in the epileptic human hippocampus

Alonso Nanclares, Lidia; Kastanauskaite, Asta; Rodriguez, Jose Rodrigo; Gonzalez Soriano, Juncal y Felipe Oroquieta, Javier de (2011). A stereological study of synapse number in the epileptic human hippocampus. "Frontiers in neuroanatomy" (n. 5); p. 29. ISSN 1662-5129. https://doi.org/10.3389/fnana.2011.00008.

Descripción

Título: A stereological study of synapse number in the epileptic human hippocampus
Autor/es:
  • Alonso Nanclares, Lidia
  • Kastanauskaite, Asta
  • Rodriguez, Jose Rodrigo
  • Gonzalez Soriano, Juncal
  • Felipe Oroquieta, Javier de
Tipo de Documento: Artículo
Título de Revista/Publicación: Frontiers in neuroanatomy
Fecha: 2011
Materias:
Escuela: Facultad de Informática (UPM) [antigua denominación]
Departamento: Otro
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Hippocampal sclerosis is the most frequent pathology encountered in resected mesial temporal structures from patients with intractable temporal lobe epilepsy (TLE). Here, we have used stereological methods to compare the overall density of synapses and neurons between non-sclerotic and sclerotic hippocampal tissue obtained by surgical resection from patients with TLE. Specifically, we examined the possible changes in the subiculum and CA1, regions that seem to be critical for the development and/or maintenance of seizures in these patients. We found a remarkable decrease in synaptic and neuronal density in the sclerotic CA1, and while the subiculum from the sclerotic hippocampus did not display changes in synaptic density, the neuronal density was higher. Since the subiculum from the sclerotic hippocampus displays a significant increase in neuronal density, as well as a various other neurochemical changes, we propose that the apparently normal subiculum from the sclerotic hippocampus suffers profound alterations in neuronal circuits at both the molecular and synaptic level that are likely to be critical for the development or maintenance of seizure activity

Más información

ID de Registro: 13668
Identificador DC: http://oa.upm.es/13668/
Identificador OAI: oai:oa.upm.es:13668
Identificador DOI: 10.3389/fnana.2011.00008
URL Oficial: http://www.frontiersin.org/Neuroanatomy/10.3389/fnana.2011.00008/abstract
Depositado por: Memoria Investigacion
Depositado el: 21 Nov 2012 08:26
Ultima Modificación: 21 Abr 2016 13:00
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