A stereological study of synapse number in the epileptic human hippocampus

Alonso Nanclares, Lidia and Kastanauskaite, Asta and Rodriguez, Jose Rodrigo and Gonzalez Soriano, Juncal and Felipe Oroquieta, Javier de (2011). A stereological study of synapse number in the epileptic human hippocampus. "Frontiers in neuroanatomy" (n. 5); p. 29. ISSN 1662-5129. https://doi.org/10.3389/fnana.2011.00008.

Description

Title: A stereological study of synapse number in the epileptic human hippocampus
Author/s:
  • Alonso Nanclares, Lidia
  • Kastanauskaite, Asta
  • Rodriguez, Jose Rodrigo
  • Gonzalez Soriano, Juncal
  • Felipe Oroquieta, Javier de
Item Type: Article
Título de Revista/Publicación: Frontiers in neuroanatomy
Date: 2011
ISSN: 1662-5129
Subjects:
Faculty: Facultad de Informática (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Hippocampal sclerosis is the most frequent pathology encountered in resected mesial temporal structures from patients with intractable temporal lobe epilepsy (TLE). Here, we have used stereological methods to compare the overall density of synapses and neurons between non-sclerotic and sclerotic hippocampal tissue obtained by surgical resection from patients with TLE. Specifically, we examined the possible changes in the subiculum and CA1, regions that seem to be critical for the development and/or maintenance of seizures in these patients. We found a remarkable decrease in synaptic and neuronal density in the sclerotic CA1, and while the subiculum from the sclerotic hippocampus did not display changes in synaptic density, the neuronal density was higher. Since the subiculum from the sclerotic hippocampus displays a significant increase in neuronal density, as well as a various other neurochemical changes, we propose that the apparently normal subiculum from the sclerotic hippocampus suffers profound alterations in neuronal circuits at both the molecular and synaptic level that are likely to be critical for the development or maintenance of seizure activity

More information

Item ID: 13668
DC Identifier: http://oa.upm.es/13668/
OAI Identifier: oai:oa.upm.es:13668
DOI: 10.3389/fnana.2011.00008
Official URL: http://www.frontiersin.org/Neuroanatomy/10.3389/fnana.2011.00008/abstract
Deposited by: Memoria Investigacion
Deposited on: 21 Nov 2012 08:26
Last Modified: 21 Apr 2016 13:00
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