Detecting reliable gene interactions by a hierarchy of Bayesian network classifiers

Armañanzas Arnedillo, Ruben and Larrañaga Múgica, Pedro and Inza Cano, Iñaki (2008). Detecting reliable gene interactions by a hierarchy of Bayesian network classifiers. "Computer Methods And Programs in Biomedicine", v. 91 (n. 2); pp. 110-121. ISSN 0169-2607. https://doi.org/10.1016/j.cmpb.2008.02.010.

Description

Title: Detecting reliable gene interactions by a hierarchy of Bayesian network classifiers
Author/s:
  • Armañanzas Arnedillo, Ruben
  • Larrañaga Múgica, Pedro
  • Inza Cano, Iñaki
Item Type: Article
Título de Revista/Publicación: Computer Methods And Programs in Biomedicine
Date: August 2008
ISSN: 0169-2607
Volume: 91
Subjects:
Faculty: Facultad de Informática (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The main purpose of a gene interaction network is to map the relationships of the genes that are out of sight when a genomic study is tackled. DNA microarrays allow the measure of gene expression of thousands of genes at the same time. These data constitute the numeric seed for the induction of the gene networks. In this paper, we propose a new approach to build gene networks by means of Bayesian classifiers, variable selection and bootstrap resampling. The interactions induced by the Bayesian classifiers are based both on the expression levels and on the phenotype information of the supervised variable. Feature selection and bootstrap resampling add reliability and robustness to the overall process removing the false positive findings. The consensus among all the induced models produces a hierarchy of dependences and, thus, of variables. Biologists can define the depth level of the model hierarchy so the set of interactions and genes involved can vary from a sparse to a dense set. Experimental results show how these networks perform well on classification tasks. The biological validation matches previous biological findings and opens new hypothesis for future studies

More information

Item ID: 13981
DC Identifier: http://oa.upm.es/13981/
OAI Identifier: oai:oa.upm.es:13981
DOI: 10.1016/j.cmpb.2008.02.010
Deposited by: Memoria Investigacion
Deposited on: 21 Dec 2012 10:27
Last Modified: 21 Apr 2016 13:26
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