Preprocessing and analyzing genetic data with complex networks: An application to Obstructive Nephropathy

Menasalvas Ruiz, Ernestina and Boccaletti, Stefano and Zanin, Massimiliano and Sousa, Pedro (2012). Preprocessing and analyzing genetic data with complex networks: An application to Obstructive Nephropathy. "Networks And Heterogeneous Media", v. 7 (n. 3); pp. 473-481. ISSN 1556-1801. https://doi.org/10.3934/nhm.2012.7.473.

Description

Title: Preprocessing and analyzing genetic data with complex networks: An application to Obstructive Nephropathy
Author/s:
  • Menasalvas Ruiz, Ernestina
  • Boccaletti, Stefano
  • Zanin, Massimiliano
  • Sousa, Pedro
Item Type: Article
Título de Revista/Publicación: Networks And Heterogeneous Media
Date: September 2012
ISSN: 1556-1801
Volume: 7
Subjects:
Freetext Keywords: Genetic data, complex networks, iterative feature selection, obstructive nephropathy, datos genéticos, redes complejas, seleción de características iterativas, nefropatía obstructiva.
Faculty: Facultad de Informática (UPM)
Department: Lenguajes y Sistemas Informáticos e Ingeniería del Software
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Many diseases have a genetic origin, and a great effort is being made to detect the genes that are responsible for their insurgence. One of the most promising techniques is the analysis of genetic information through the use of complex networks theory. Yet, a practical problem of this approach is its computational cost, which scales as the square of the number of features included in the initial dataset. In this paper, we propose the use of an iterative feature selection strategy to identify reduced subsets of relevant features, and show an application to the analysis of congenital Obstructive Nephropathy. Results demonstrate that, besides achieving a drastic reduction of the computational cost, the topologies of the obtained networks still hold all the relevant information, and are thus able to fully characterize the severity of the disease.

More information

Item ID: 15534
DC Identifier: http://oa.upm.es/15534/
OAI Identifier: oai:oa.upm.es:15534
DOI: 10.3934/nhm.2012.7.473
Official URL: http://www.aimsciences.org/journals/displayArticlesnew.jsp?paperID=7799
Deposited by: Memoria Investigacion
Deposited on: 03 Jun 2013 17:40
Last Modified: 21 Apr 2016 15:38
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