Monte-Carlo dosimetry on a realistic cell monolayer geometry exposed to alpha particles

Barberet, Philippe; Vianna, François; Karamitros, M.; Brun, T.; Gordillo Garcia, Nuria; Moretto, Philippe; Incerti, Sébastien y Seznec, H. (2012). Monte-Carlo dosimetry on a realistic cell monolayer geometry exposed to alpha particles. "Physics in Medicine and Biology", v. 57 (n. 8); pp. 2189-2207. ISSN 0031-9155. https://doi.org/10.1088/0031-9155/57/8/2189.

Descripción

Título: Monte-Carlo dosimetry on a realistic cell monolayer geometry exposed to alpha particles
Autor/es:
  • Barberet, Philippe
  • Vianna, François
  • Karamitros, M.
  • Brun, T.
  • Gordillo Garcia, Nuria
  • Moretto, Philippe
  • Incerti, Sébastien
  • Seznec, H.
Tipo de Documento: Artículo
Título de Revista/Publicación: Physics in Medicine and Biology
Fecha: Abril 2012
Volumen: 57
Materias:
Escuela: E.T.S.I. Industriales (UPM)
Departamento: Ingeniería Nuclear [hasta 2014]
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

The energy and specific energy absorbed in the main cell compartments (nucleus and cytoplasm) in typical radiobiology experiments are usually estimated by calculations as they are not accessible for a direct measurement. In most of the work, the cell geometry is modelled using the combination of simple mathematical volumes. We propose a method based on high resolution confocal imaging and ion beam analysis (IBA) in order to import realistic cell nuclei geometries in Monte-Carlo simulations and thus take into account the variety of different geometries encountered in a typical cell population. Seventy-six cell nuclei have been imaged using confocal microscopy and their chemical composition has been measured using IBA. A cellular phantom was created from these data using the ImageJ image analysis software and imported in the Geant4 Monte-Carlo simulation toolkit. Total energy and specific energy distributions in the 76 cell nuclei have been calculated for two types of irradiation protocols: a 3 MeV alpha particle microbeam used for targeted irradiation and a 239Pu alpha source used for large angle random irradiation. Qualitative images of the energy deposited along the particle tracks have been produced and show good agreement with images of DNA double strand break signalling proteins obtained experimentally. The methodology presented in this paper provides microdosimetric quantities calculated from realistic cellular volumes. It is based on open-source oriented software that is publicly available.

Más información

ID de Registro: 15955
Identificador DC: http://oa.upm.es/15955/
Identificador OAI: oai:oa.upm.es:15955
Identificador DOI: 10.1088/0031-9155/57/8/2189
URL Oficial: http://iopscience.iop.org/0031-9155/57/8/2189/
Depositado por: Memoria Investigacion
Depositado el: 17 Dic 2013 19:30
Ultima Modificación: 21 Abr 2016 16:16
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