Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes

Dueñas, Marta and Santos, Mirentxu and Aranda, Juan F. and Bielza, Concha and Martínez-Cruz, Ana B. and Lorz, Corina and Taron, Miquel and Ciruelos, Eva M. and Rodríguez-Peralto, José L. and Martín Jiménez, Miguel and Larrañaga Múgica, Pedro and Dahabreh, Jubrail and Stathopoulos, George P. and Rosell, Rafael and Paramio, Jesús M. and García-Escudero, Ramón (2012). Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes. "Plos One", v. 7 (n. 8); pp.. ISSN 1932-6203. https://doi.org/10.1371/journal.pone.0042494.

Description

Title: Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes
Author/s:
  • Dueñas, Marta
  • Santos, Mirentxu
  • Aranda, Juan F.
  • Bielza, Concha
  • Martínez-Cruz, Ana B.
  • Lorz, Corina
  • Taron, Miquel
  • Ciruelos, Eva M.
  • Rodríguez-Peralto, José L.
  • Martín Jiménez, Miguel
  • Larrañaga Múgica, Pedro
  • Dahabreh, Jubrail
  • Stathopoulos, George P.
  • Rosell, Rafael
  • Paramio, Jesús M.
  • García-Escudero, Ramón
Item Type: Article
Título de Revista/Publicación: Plos One
Date: 7 August 2012
ISSN: 1932-6203
Volume: 7
Subjects:
Faculty: Facultad de Informática (UPM)
Department: Inteligencia Artificial
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.

More information

Item ID: 16431
DC Identifier: http://oa.upm.es/16431/
OAI Identifier: oai:oa.upm.es:16431
DOI: 10.1371/journal.pone.0042494
Official URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042494
Deposited by: Memoria Investigacion
Deposited on: 12 Jul 2013 15:12
Last Modified: 21 Apr 2016 16:44
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