Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes

Dueñas, Marta; Santos, Mirentxu; Aranda, Juan F.; Bielza, Concha; Martínez-Cruz, Ana B.; Lorz, Corina; Taron, Miquel; Ciruelos, Eva M.; Rodríguez-Peralto, José L.; Martín Jiménez, Miguel; Larrañaga Múgica, Pedro; Dahabreh, Jubrail; Stathopoulos, George P.; Rosell, Rafael; Paramio, Jesús M. y García-Escudero, Ramón (2012). Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes. "Plos One", v. 7 (n. 8); pp.. ISSN 1932-6203. https://doi.org/10.1371/journal.pone.0042494.

Descripción

Título: Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes
Autor/es:
  • Dueñas, Marta
  • Santos, Mirentxu
  • Aranda, Juan F.
  • Bielza, Concha
  • Martínez-Cruz, Ana B.
  • Lorz, Corina
  • Taron, Miquel
  • Ciruelos, Eva M.
  • Rodríguez-Peralto, José L.
  • Martín Jiménez, Miguel
  • Larrañaga Múgica, Pedro
  • Dahabreh, Jubrail
  • Stathopoulos, George P.
  • Rosell, Rafael
  • Paramio, Jesús M.
  • García-Escudero, Ramón
Tipo de Documento: Artículo
Título de Revista/Publicación: Plos One
Fecha: 7 Agosto 2012
Volumen: 7
Materias:
Escuela: Facultad de Informática (UPM) [antigua denominación]
Departamento: Inteligencia Artificial
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

Texto completo

[img]
Vista Previa
PDF (Document Portable Format) - Se necesita un visor de ficheros PDF, como GSview, Xpdf o Adobe Acrobat Reader
Descargar (1MB) | Vista Previa

Resumen

Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.

Más información

ID de Registro: 16431
Identificador DC: http://oa.upm.es/16431/
Identificador OAI: oai:oa.upm.es:16431
Identificador DOI: 10.1371/journal.pone.0042494
URL Oficial: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042494
Depositado por: Memoria Investigacion
Depositado el: 12 Jul 2013 15:12
Ultima Modificación: 21 Abr 2016 16:44
  • Open Access
  • Open Access
  • Sherpa-Romeo
    Compruebe si la revista anglosajona en la que ha publicado un artículo permite también su publicación en abierto.
  • Dulcinea
    Compruebe si la revista española en la que ha publicado un artículo permite también su publicación en abierto.
  • Recolecta
  • e-ciencia
  • Observatorio I+D+i UPM
  • OpenCourseWare UPM