Brain structural and functional recovery following initiation of combination antiretroviral therapy

Becker, James T. and Cuesta, Pablo and Fabrizio, Melissa and Sudre, Gustavo and Vergis, Emanuel N. and Douaihy, Antoine and Bajo Breton, Ricardo and Schubert, Allie and Lopez, Oscar L. and Parkkonen, Lauri and Maestú, Fernando and Bagic, Anto (2012). Brain structural and functional recovery following initiation of combination antiretroviral therapy. "Journal of NeuroVirology", v. 18 (n. 5); pp. 423-427. ISSN 1355-0284. https://doi.org/10.1007/s13365-012-0115-0.

Description

Title: Brain structural and functional recovery following initiation of combination antiretroviral therapy
Author/s:
  • Becker, James T.
  • Cuesta, Pablo
  • Fabrizio, Melissa
  • Sudre, Gustavo
  • Vergis, Emanuel N.
  • Douaihy, Antoine
  • Bajo Breton, Ricardo
  • Schubert, Allie
  • Lopez, Oscar L.
  • Parkkonen, Lauri
  • Maestú, Fernando
  • Bagic, Anto
Item Type: Article
Título de Revista/Publicación: Journal of NeuroVirology
Date: October 2012
ISSN: 1355-0284
Volume: 18
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

NeuroAIDS persists in the era of combination antiretroviral therapies. We describe here the recovery of brain structure and function following 6 months of therapy in a treatment-naive patient presenting with HIV-associated dementia. The patient’s neuropsychological test performance improved and his total brain volume increased by more than 5 %. Neuronal functional connectivity measured by magnetoencephalography changed from a pattern identical to that observed in other HIV-infected individuals to one that was indistinguishable from that of uninfected control subjects. These data suggest that at least some of the effects of HIV on the brain can be fully reversed with treatment.

More information

Item ID: 16574
DC Identifier: http://oa.upm.es/16574/
OAI Identifier: oai:oa.upm.es:16574
DOI: 10.1007/s13365-012-0115-0
Official URL: http://link.springer.com/article/10.1007%2Fs13365-012-0115-0
Deposited by: Memoria Investigacion
Deposited on: 17 Oct 2013 18:00
Last Modified: 21 Apr 2016 16:54
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