Becker, James T. and Cuesta, Pablo and Fabrizio, Melissa and Sudre, Gustavo and Vergis, Emanuel N. and Douaihy, Antoine and Bajo Breton, Ricardo and Schubert, Allie and Lopez, Oscar L. and Parkkonen, Lauri and Maestú, Fernando and Bagic, Anto
Brain structural and functional recovery following initiation of combination antiretroviral therapy.
"Journal of NeuroVirology", v. 18
NeuroAIDS persists in the era of combination antiretroviral therapies. We describe here the recovery of brain structure and function following 6 months of therapy in a treatment-naive patient presenting with HIV-associated dementia. The patient’s neuropsychological test performance improved and his total brain volume increased by more than 5 %. Neuronal functional connectivity measured by magnetoencephalography changed from a pattern identical to that observed in other HIV-infected individuals to one that was indistinguishable from that of uninfected control subjects. These data suggest that at least some of the effects of HIV on the brain can be fully reversed with treatment.