Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints

Bajo Breton, Ricardo; Perales Castellanos, Nazareth; López García, María Eugenia; Ruiz Sanchez de León, José María; Montejo Carrasco, Pedro; Montenegro Peña, Mercedes; Llanero Luque, Marcos; Gil Gregorio, Pedro; Yubero Pancorbo, Raquel; Baykova, Evgenia; Paúl, Nuria; Aurtenetxe, Sara; Pozo Guerrero, Francisco del y Maestú, Fernando (2012). Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints. "AGE", v. 34 (n. 2); pp. 497-506. ISSN 0161-9152. https://doi.org/10.1007/s11357-011-9241-5.

Descripción

Título: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints
Autor/es:
  • Bajo Breton, Ricardo
  • Perales Castellanos, Nazareth
  • López García, María Eugenia
  • Ruiz Sanchez de León, José María
  • Montejo Carrasco, Pedro
  • Montenegro Peña, Mercedes
  • Llanero Luque, Marcos
  • Gil Gregorio, Pedro
  • Yubero Pancorbo, Raquel
  • Baykova, Evgenia
  • Paúl, Nuria
  • Aurtenetxe, Sara
  • Pozo Guerrero, Francisco del
  • Maestú, Fernando
Tipo de Documento: Artículo
Título de Revista/Publicación: AGE
Fecha: Abril 2012
Volumen: 34
Materias:
Palabras Clave Informales: Subjective memory complaints, Mild cognitive impairment, Magnetoencephalography, Alzheimer's disease, Functional connectivity, Synchronization Likelihood
Escuela: E.T.S.I. Telecomunicación (UPM)
Departamento: Tecnología Fotónica [hasta 2014]
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

It is still an open question whether subjective memory complaints (SMC) can actually be considered to be clinically relevant predictors for the development of an objective memory impairment and even dementia. There is growing evidence that suggests that SMC are associated with an increased risk of dementia and with the presence of biological correlates of early Alzheimer's disease. In this paper, in order to shed some light on this issue, we try to discern whether subjects with SMC showed a different profile of functional connectivity compared with subjects with mild cognitive impairment (MCI) and healthy elderly subjects. In the present study, we compare the degree of synchronization of brain signals recorded with magnetoencephalography between three groups of subjects (56 in total): 19 with MCI, 12 with SMC and 25 healthy controls during a memory task. Synchronization likelihood, an index based on the theory of nonlinear dynamical systems, was used to measure functional connectivity. Briefly, results show that subjects with SMC have a very similar pattern of connectivity to control group, but on average, they present a lower synchronization value. These results could indicate that SMC are representing an initial stage with a hypo-synchronization (in comparison with the control group) where the brain system is still not compensating for the failing memory networks, but behaving as controls when compared with the MCI subjects.

Más información

ID de Registro: 16575
Identificador DC: http://oa.upm.es/16575/
Identificador OAI: oai:oa.upm.es:16575
Identificador DOI: 10.1007/s11357-011-9241-5
URL Oficial: http://link.springer.com/article/10.1007%2Fs11357-011-9241-5
Depositado por: Memoria Investigacion
Depositado el: 21 Jul 2013 10:34
Ultima Modificación: 21 Abr 2016 16:54
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