Thermal and mechanical effects of different excitation modes based on low frequency laser modulation in optical hyperthermia

Sanchez Lopez de Pablo, Cristina and Ramos Gomez, Milagros and Fernáncez Cabada, Tamara and Ramos Ávila, Julio Alberto and Martínez, Alberto and Pozo Guerrero, Francisco del and Serrano Olmedo, Jose Javier (2012). Thermal and mechanical effects of different excitation modes based on low frequency laser modulation in optical hyperthermia. In: "13th edition of Trends in Nanotechnology International Conference (TNT2012)", 10/09/2012 - 14/09/2012, Madrid, España. pp. 170-171.

Description

Title: Thermal and mechanical effects of different excitation modes based on low frequency laser modulation in optical hyperthermia
Author/s:
  • Sanchez Lopez de Pablo, Cristina
  • Ramos Gomez, Milagros
  • Fernáncez Cabada, Tamara
  • Ramos Ávila, Julio Alberto
  • Martínez, Alberto
  • Pozo Guerrero, Francisco del
  • Serrano Olmedo, Jose Javier
Item Type: Presentation at Congress or Conference (Article)
Event Title: 13th edition of Trends in Nanotechnology International Conference (TNT2012)
Event Dates: 10/09/2012 - 14/09/2012
Event Location: Madrid, España
Title of Book: TNT 2012 Proceedings
Date: 2012
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

[img]
Preview
PDF - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (2MB) | Preview

Abstract

The low frequency modulation of the laser source (menor que30KHz) allows the generation of a pulsed signal that intermittently excites the gold nanorods. The temperature curves obtained for different frequencies and duty cycles of modulation but with equal average power and identical laser parameters, show that the thermal behavior in continuous wave and modulation modes is the same. However, the cell death experiments suggest that the percentage of death is higher in the cases of modulation. This observation allows us to conclude that there are other effects in addition to temperature that contribute to the cellular death. The mechanical effects like sound or pressure waves are expected to be generated from thermal expansion of gold nanorods. In order to study the behavior and magnitude of these processes we have developed a measure device based on ultrasound piezoelectric receivers (25KHz) and a lock-in amplifier that is able to detect the sound waves generated in samples of gold nanorods during laser irradiation providing us a voltage result proportional to the pressure signal. The first results show that the pressure measurements are directly proportional to the concentration of gold nanorods and the laser power, therefore, our present work is focused on determine the real influence of these effects in the cell death process.

More information

Item ID: 20582
DC Identifier: http://oa.upm.es/20582/
OAI Identifier: oai:oa.upm.es:20582
Official URL: http://www.tntconf.org/2012/index.php?conf=12
Deposited by: Memoria Investigacion
Deposited on: 11 Oct 2013 13:43
Last Modified: 04 Mar 2015 16:22
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM