Thermal and mechanical effects of different excitation modes based on low frequency laser modulation in optical hyperthermia

Sanchez Lopez de Pablo, Cristina; Ramos Gomez, Milagros; Fernáncez Cabada, Tamara; Ramos Ávila, Julio Alberto; Martínez, Alberto; Pozo Guerrero, Francisco del y Serrano Olmedo, Jose Javier (2012). Thermal and mechanical effects of different excitation modes based on low frequency laser modulation in optical hyperthermia. En: "13th edition of Trends in Nanotechnology International Conference (TNT2012)", 10/09/2012 - 14/09/2012, Madrid, España. pp. 170-171.

Descripción

Título: Thermal and mechanical effects of different excitation modes based on low frequency laser modulation in optical hyperthermia
Autor/es:
  • Sanchez Lopez de Pablo, Cristina
  • Ramos Gomez, Milagros
  • Fernáncez Cabada, Tamara
  • Ramos Ávila, Julio Alberto
  • Martínez, Alberto
  • Pozo Guerrero, Francisco del
  • Serrano Olmedo, Jose Javier
Tipo de Documento: Ponencia en Congreso o Jornada (Artículo)
Título del Evento: 13th edition of Trends in Nanotechnology International Conference (TNT2012)
Fechas del Evento: 10/09/2012 - 14/09/2012
Lugar del Evento: Madrid, España
Título del Libro: TNT 2012 Proceedings
Fecha: 2012
Materias:
Escuela: Centro de Tecnología Biomédica (CTB) (UPM)
Departamento: Otro
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

The low frequency modulation of the laser source (menor que30KHz) allows the generation of a pulsed signal that intermittently excites the gold nanorods. The temperature curves obtained for different frequencies and duty cycles of modulation but with equal average power and identical laser parameters, show that the thermal behavior in continuous wave and modulation modes is the same. However, the cell death experiments suggest that the percentage of death is higher in the cases of modulation. This observation allows us to conclude that there are other effects in addition to temperature that contribute to the cellular death. The mechanical effects like sound or pressure waves are expected to be generated from thermal expansion of gold nanorods. In order to study the behavior and magnitude of these processes we have developed a measure device based on ultrasound piezoelectric receivers (25KHz) and a lock-in amplifier that is able to detect the sound waves generated in samples of gold nanorods during laser irradiation providing us a voltage result proportional to the pressure signal. The first results show that the pressure measurements are directly proportional to the concentration of gold nanorods and the laser power, therefore, our present work is focused on determine the real influence of these effects in the cell death process.

Más información

ID de Registro: 20582
Identificador DC: http://oa.upm.es/20582/
Identificador OAI: oai:oa.upm.es:20582
URL Oficial: http://www.tntconf.org/2012/index.php?conf=12
Depositado por: Memoria Investigacion
Depositado el: 11 Oct 2013 13:43
Ultima Modificación: 04 Mar 2015 16:22
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