A computational model coupling mechanics and electrophysiology in spinal cord injury

Jérusalem, Antoine; García Grajales, Julián Andrés; Merchan Perez, Angel y Peña Sanchez, Jose Maria (2014). A computational model coupling mechanics and electrophysiology in spinal cord injury. "Biomechanics and Modeling in Mechanobiology", v. 13 (n. 4); pp. 883-896. ISSN 1617-7959. https://doi.org/10.1007/s10237-013-0543-7.

Descripción

Título: A computational model coupling mechanics and electrophysiology in spinal cord injury
Autor/es:
  • Jérusalem, Antoine
  • García Grajales, Julián Andrés
  • Merchan Perez, Angel
  • Peña Sanchez, Jose Maria
Tipo de Documento: Artículo
Título de Revista/Publicación: Biomechanics and Modeling in Mechanobiology
Fecha: Agosto 2014
Volumen: 13
Materias:
Palabras Clave Informales: Computational model, axon, electrophysiology, mechanics, spinal cord injury
Escuela: Centro de Supercomputación y Visualización de Madrid (CeSViMa) (UPM)
Departamento: Otro
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Traumatic brain injury and spinal cord injury have recently been put under the spotlight as major causes of death and disability in the developed world. Despite the important ongoing experimental and modeling campaigns aimed at understanding the mechanics of tissue and cell damage typically observed in such events, the differenti- ated roles of strain, stress and their corresponding loading rates on the damage level itself remain unclear. More specif- ically, the direct relations between brain and spinal cord tis- sue or cell damage, and electrophysiological functions are still to be unraveled. Whereas mechanical modeling efforts are focusing mainly on stress distribution and mechanistic- based damage criteria, simulated function-based damage cri- teria are still missing. Here, we propose a new multiscale model of myelinated axon associating electrophysiological impairment to structural damage as a function of strain and strain rate. This multiscale approach provides a new framework for damage evaluation directly relating neuron mechanics and electrophysiological properties, thus provid- ing a link between mechanical trauma and subsequent func- tional deficits.

Más información

ID de Registro: 25890
Identificador DC: http://oa.upm.es/25890/
Identificador OAI: oai:oa.upm.es:25890
Identificador DOI: 10.1007/s10237-013-0543-7
URL Oficial: http://link.springer.com/article/10.1007%2Fs10237-013-0543-7
Depositado por: Memoria Investigacion
Depositado el: 18 Abr 2015 08:27
Ultima Modificación: 01 Sep 2015 22:56
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