A computational model coupling mechanics and electrophysiology in spinal cord injury

Jérusalem, Antoine and García Grajales, Julián Andrés and Merchan Perez, Angel and Peña Sanchez, Jose Maria (2014). A computational model coupling mechanics and electrophysiology in spinal cord injury. "Biomechanics and Modeling in Mechanobiology", v. 13 (n. 4); pp. 883-896. ISSN 1617-7959. https://doi.org/10.1007/s10237-013-0543-7.

Description

Title: A computational model coupling mechanics and electrophysiology in spinal cord injury
Author/s:
  • Jérusalem, Antoine
  • García Grajales, Julián Andrés
  • Merchan Perez, Angel
  • Peña Sanchez, Jose Maria
Item Type: Article
Título de Revista/Publicación: Biomechanics and Modeling in Mechanobiology
Date: August 2014
ISSN: 1617-7959
Volume: 13
Subjects:
Freetext Keywords: Computational model, axon, electrophysiology, mechanics, spinal cord injury
Faculty: Centro de Supercomputación y Visualización de Madrid (CeSViMa) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

[img]
Preview
PDF - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (6MB) | Preview

Abstract

Traumatic brain injury and spinal cord injury have recently been put under the spotlight as major causes of death and disability in the developed world. Despite the important ongoing experimental and modeling campaigns aimed at understanding the mechanics of tissue and cell damage typically observed in such events, the differenti- ated roles of strain, stress and their corresponding loading rates on the damage level itself remain unclear. More specif- ically, the direct relations between brain and spinal cord tis- sue or cell damage, and electrophysiological functions are still to be unraveled. Whereas mechanical modeling efforts are focusing mainly on stress distribution and mechanistic- based damage criteria, simulated function-based damage cri- teria are still missing. Here, we propose a new multiscale model of myelinated axon associating electrophysiological impairment to structural damage as a function of strain and strain rate. This multiscale approach provides a new framework for damage evaluation directly relating neuron mechanics and electrophysiological properties, thus provid- ing a link between mechanical trauma and subsequent func- tional deficits.

More information

Item ID: 25890
DC Identifier: http://oa.upm.es/25890/
OAI Identifier: oai:oa.upm.es:25890
DOI: 10.1007/s10237-013-0543-7
Official URL: http://link.springer.com/article/10.1007%2Fs10237-013-0543-7
Deposited by: Memoria Investigacion
Deposited on: 18 Apr 2015 08:27
Last Modified: 01 Sep 2015 22:56
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM