Bile Acids Induce Glucagon-Like Peptide 2 Secretion with Limited Effects on Intestinal Adaptation in Early Weaned Pigs

Ipharraguerre, Ignacio; Tedó, Gemma; Menoyo Luque, David; De Diego Cabero, Nuria; Holst, Jens J.; Nofrarías, Miquel; Mereu, Alessandro y Burrin, Douglas G. (2013). Bile Acids Induce Glucagon-Like Peptide 2 Secretion with Limited Effects on Intestinal Adaptation in Early Weaned Pigs. "Journal of Nutrition", v. 143 (n. 12); pp. 1899-1905. ISSN 0022-3166. https://doi.org/10.3945/jn.113.177865.

Descripción

Título: Bile Acids Induce Glucagon-Like Peptide 2 Secretion with Limited Effects on Intestinal Adaptation in Early Weaned Pigs
Autor/es:
  • Ipharraguerre, Ignacio
  • Tedó, Gemma
  • Menoyo Luque, David
  • De Diego Cabero, Nuria
  • Holst, Jens J.
  • Nofrarías, Miquel
  • Mereu, Alessandro
  • Burrin, Douglas G.
Tipo de Documento: Artículo
Título de Revista/Publicación: Journal of Nutrition
Fecha: Diciembre 2013
Volumen: 143
Materias:
Escuela: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Departamento: Producción Animal [hasta 2014]
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Early weaning is a stressful event characterized by a transient period of intestinal atrophy that may be mediated by reduced secretion of glucagon-like peptide (GLP) 2. We tested whether enterally fed bile acids or plant sterols could increase nutrient-dependent GLP-2 secretion and improve intestinal adaptation in weanling pigs. During the first 6 d after weaning, piglets were intragastrically infused once daily with either deionized water -control-, chenodeoxycholic acid -CDC; 60mg/kg body weight-, or b-sitoesterol -BSE; 100 mg/kg body weight-. Infusing CDC increased plasma GLP-2 -P menor que 0.05- but did not affect plasma GLP-1 and feed intake. The intestinal expression of Glp2r -glucagon-like peptide 2 receptor-, Asbt -sodium-dependent bile acid transporter-, Fxr -farnesoid X receptor-, and Tgr5 -guanosine protein?coupled bile acid receptor- genes were not affected by CDC treatment. The intragastric administration of CDC did not alter the weight and length of the intestine, yet increased the activation of caspase-3 in ileal villi -P menor que 0.02- and the expression of Il6 -interleukin 6; P menor que 0.002- in the jejunum. In contrast, infusing BSE did not affect any of the variables that were measured. Our results show that the enteral administration of the bile acid CDC potentiates the nutrient-induced secretion of endogenous GLP-2 in early-weaned pigs. Bile acid?enhanced release of GLP-2, however, did not result in improved intestinal growth, morphology, or inflammation during the postweaning degenerative phase.

Más información

ID de Registro: 26241
Identificador DC: http://oa.upm.es/26241/
Identificador OAI: oai:oa.upm.es:26241
Identificador DOI: 10.3945/jn.113.177865
URL Oficial: http://jn.nutrition.org/content/143/12/1899.abstract?sid=261a953a-1602-45ff-9abf-13aa8ff40318
Depositado por: Memoria Investigacion
Depositado el: 23 Jun 2014 13:37
Ultima Modificación: 22 Sep 2014 11:40
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