FocusDET, a new toolbox for SISCOM analysis. Evaluation of the registration accuracy using monte carlo simulation

Martí Fuster, B. and Esteban, Oscar and Planes Cid, X. and Aguiar, Pablo and Crespo, Cristina and Falcon, Carles and Wollny, Gert and Rubí Sureda, Sebastià and Setoain Perego, X. and Frangi Caregnato, A.F. and Ledesma Carbayo, María Jesús and Santos Lleo, Andres de and Pavía Segura, J. and Ros Puig, D. (2013). FocusDET, a new toolbox for SISCOM analysis. Evaluation of the registration accuracy using monte carlo simulation. "Neuroinformatics", v. 11 (n. 1); pp. 77-89. ISSN 1539-2791. https://doi.org/10.1007/s12021-012-9158-x.

Description

Title: FocusDET, a new toolbox for SISCOM analysis. Evaluation of the registration accuracy using monte carlo simulation
Author/s:
  • Martí Fuster, B.
  • Esteban, Oscar
  • Planes Cid, X.
  • Aguiar, Pablo
  • Crespo, Cristina
  • Falcon, Carles
  • Wollny, Gert
  • Rubí Sureda, Sebastià
  • Setoain Perego, X.
  • Frangi Caregnato, A.F.
  • Ledesma Carbayo, María Jesús
  • Santos Lleo, Andres de
  • Pavía Segura, J.
  • Ros Puig, D.
Item Type: Article
Título de Revista/Publicación: Neuroinformatics
Date: January 2013
ISSN: 1539-2791
Volume: 11
Subjects:
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Ingeniería Electrónica
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Subtraction of Ictal SPECT Co-registered to MRI (SISCOM) is an imaging technique used to localize the epileptogenic focus in patients with intractable partial epilepsy. The aim of this study was to determine the accuracy of registration algorithms involved in SISCOM analysis using FocusDET, a new user-friendly application. To this end, Monte Carlo simulation was employed to generate realistic SPECT studies. Simulated sinograms were reconstructed by using the Filtered BackProjection (FBP) algorithm and an Ordered Subsets Expectation Maximization (OSEM) reconstruction method that included compensation for all degradations. Registration errors in SPECT-SPECT and SPECT-MRI registration were evaluated by comparing the theoretical and actual transforms. Patient studies with well-localized epilepsy were also included in the registration assessment. Global registration errors including SPECT-SPECT and SPECT-MRI registration errors were less than 1.2 mm on average, exceeding the voxel size (3.32 mm) of SPECT studies in no case. Although images reconstructed using OSEM led to lower registration errors than images reconstructed with FBP, differences after using OSEM or FBP in reconstruction were less than 0.2 mm on average. This indicates that correction for degradations does not play a major role in the SISCOM process, thereby facilitating the application of the methodology in centers where OSEM is not implemented with correction of all degradations. These findings together with those obtained by clinicians from patients via MRI, interictal and ictal SPECT and video-EEG, show that FocusDET is a robust application for performing SISCOM analysis in clinical practice.

More information

Item ID: 26814
DC Identifier: http://oa.upm.es/26814/
OAI Identifier: oai:oa.upm.es:26814
DOI: 10.1007/s12021-012-9158-x
Official URL: http://link.springer.com/journal/12021/11/1/page/1
Deposited by: Memoria Investigacion
Deposited on: 31 May 2014 11:03
Last Modified: 25 May 2015 14:45
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