Stability and mechanical evaluation of bovine pericardium cross-linked with polyurethane prepolymer in aqueous medium

Mendoza Novelo, Birzabit; Alvarado Castro, Diego I.; Mata Mata, José L.; Cauich Rodríguez, Juan V.; Vega González, Arturo; Jorge Herrero, Eduardo; Rojo Pérez, Francisco Javier y Guinea Tortuero, Gustavo V. (2013). Stability and mechanical evaluation of bovine pericardium cross-linked with polyurethane prepolymer in aqueous medium. "Materials science and engineering. C, Materials for biological applications", v. 33 (n. 4); pp. 2392-2398. ISSN 0928-4931. https://doi.org/10.1016/j.msec2013.02.001.

Descripción

Título: Stability and mechanical evaluation of bovine pericardium cross-linked with polyurethane prepolymer in aqueous medium
Autor/es:
  • Mendoza Novelo, Birzabit
  • Alvarado Castro, Diego I.
  • Mata Mata, José L.
  • Cauich Rodríguez, Juan V.
  • Vega González, Arturo
  • Jorge Herrero, Eduardo
  • Rojo Pérez, Francisco Javier
  • Guinea Tortuero, Gustavo V.
Tipo de Documento: Artículo
Título de Revista/Publicación: Materials science and engineering. C, Materials for biological applications
Fecha: 1 Mayo 2013
Volumen: 33
Materias:
Escuela: E.T.S.I. Caminos, Canales y Puertos (UPM)
Departamento: Ciencia de los Materiales
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

The present study investigates the potential use of non-catalyzed water-soluble blocked polyurethane prepolymer (PUP) as a bifunctional cross-linker for collagenous scaffolds. The effect of concentration (5, 10, 15 and 20%), time (4, 6, 12 and 24 h), medium volume (50, 100, 200 and 300%) and pH (7.4, 8.2, 9 and 10) over stability, microstructure and tensile mechanical behavior of acellular pericardial matrix was studied. The cross-linking index increased up to 81% while the denaturation temperature increased up to 12 °C after PUP crosslinking. PUP-treated scaffold resisted the collagenase degradation (0.167 ± 0.14 mmol/g of liberated amine groups vs. 598 ± 60 mmol/g for non-cross-linked matrix). The collagen fiber network was coated with PUP while viscoelastic properties were altered after cross-linking. The treatment of the pericardial scaffold with PUP allows (i) different densities of cross-linking depending of the process parameters and (ii) tensile properties similar to glutaraldehyde method.

Más información

ID de Registro: 29067
Identificador DC: http://oa.upm.es/29067/
Identificador OAI: oai:oa.upm.es:29067
Identificador DOI: 10.1016/j.msec2013.02.001
URL Oficial: http://www.sciencedirect.com/science/article/pii/S092849311300101X
Depositado por: Memoria Investigacion
Depositado el: 30 Jun 2014 12:41
Ultima Modificación: 01 May 2015 22:56
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