Stability and mechanical evaluation of bovine pericardium cross-linked with polyurethane prepolymer in aqueous medium

Mendoza Novelo, Birzabit and Alvarado Castro, Diego I. and Mata Mata, José L. and Cauich Rodríguez, Juan V. and Vega González, Arturo and Jorge Herrero, Eduardo and Rojo Pérez, Francisco Javier and Guinea Tortuero, Gustavo V. (2013). Stability and mechanical evaluation of bovine pericardium cross-linked with polyurethane prepolymer in aqueous medium. "Materials science and engineering. C, Materials for biological applications", v. 33 (n. 4); pp. 2392-2398. ISSN 0928-4931. https://doi.org/10.1016/j.msec2013.02.001.

Description

Title: Stability and mechanical evaluation of bovine pericardium cross-linked with polyurethane prepolymer in aqueous medium
Author/s:
  • Mendoza Novelo, Birzabit
  • Alvarado Castro, Diego I.
  • Mata Mata, José L.
  • Cauich Rodríguez, Juan V.
  • Vega González, Arturo
  • Jorge Herrero, Eduardo
  • Rojo Pérez, Francisco Javier
  • Guinea Tortuero, Gustavo V.
Item Type: Article
Título de Revista/Publicación: Materials science and engineering. C, Materials for biological applications
Date: 1 May 2013
ISSN: 0928-4931
Volume: 33
Subjects:
Faculty: E.T.S.I. Caminos, Canales y Puertos (UPM)
Department: Ciencia de los Materiales
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The present study investigates the potential use of non-catalyzed water-soluble blocked polyurethane prepolymer (PUP) as a bifunctional cross-linker for collagenous scaffolds. The effect of concentration (5, 10, 15 and 20%), time (4, 6, 12 and 24 h), medium volume (50, 100, 200 and 300%) and pH (7.4, 8.2, 9 and 10) over stability, microstructure and tensile mechanical behavior of acellular pericardial matrix was studied. The cross-linking index increased up to 81% while the denaturation temperature increased up to 12 °C after PUP crosslinking. PUP-treated scaffold resisted the collagenase degradation (0.167 ± 0.14 mmol/g of liberated amine groups vs. 598 ± 60 mmol/g for non-cross-linked matrix). The collagen fiber network was coated with PUP while viscoelastic properties were altered after cross-linking. The treatment of the pericardial scaffold with PUP allows (i) different densities of cross-linking depending of the process parameters and (ii) tensile properties similar to glutaraldehyde method.

More information

Item ID: 29067
DC Identifier: http://oa.upm.es/29067/
OAI Identifier: oai:oa.upm.es:29067
DOI: 10.1016/j.msec2013.02.001
Official URL: http://www.sciencedirect.com/science/article/pii/S092849311300101X
Deposited by: Memoria Investigacion
Deposited on: 30 Jun 2014 12:41
Last Modified: 01 May 2015 22:56
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