A method to obtain the thermal parameters and the photothermal transduction efficiency in an optical hyperthermia device based on laser irradiation of gold nanoparticles

Sánchez López de Pablo, Cristina; Serrano Olmedo, Jose Javier; Mina Rosales, Alejandra; Ramírez Hernández, Norma y Pozo Guerrero, Francisco del (2014). A method to obtain the thermal parameters and the photothermal transduction efficiency in an optical hyperthermia device based on laser irradiation of gold nanoparticles. "Nanoscale Research Letters", v. 9 (n. 441); pp. 1-7. ISSN 1931-7573. https://doi.org/10.1186/1556-276X-9-441.

Descripción

Título: A method to obtain the thermal parameters and the photothermal transduction efficiency in an optical hyperthermia device based on laser irradiation of gold nanoparticles
Autor/es:
  • Sánchez López de Pablo, Cristina
  • Serrano Olmedo, Jose Javier
  • Mina Rosales, Alejandra
  • Ramírez Hernández, Norma
  • Pozo Guerrero, Francisco del
Tipo de Documento: Artículo
Título de Revista/Publicación: Nanoscale Research Letters
Fecha: Agosto 2014
Volumen: 9
Materias:
Palabras Clave Informales: Gold nanoparticles; Laser irradiation; Optical hyperthermia; Photothermal transduction efficiency; Temperature curves; Thermal parameters
Escuela: Centro de Tecnología Biomédica (CTB) (UPM)
Departamento: Otro
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Optical hyperthermia systems based on the laser irradiation of gold nanorods seem to be a promising tool in the development of therapies against cancer. After a proof of concept in which the authors demonstrated the efficiency of this kind of systems, a modeling process based on an equivalent thermal-electric circuit has been carried out to determine the thermal parameters of the system and an energy balance obtained from the time-dependent heating and cooling temperature curves of the irradiated samples in order to obtain the photothermal transduction efficiency. By knowing this parameter, it is possible to increase the effectiveness of the treatments, thanks to the possibility of predicting the response of the device depending on the working configuration. As an example, the thermal behavior of two different kinds of nanoparticles is compared. The results show that, under identical conditions, the use of PEGylated gold nanorods allows for a more efficient heating compared with bare nanorods, and therefore, it results in a more effective therapy.

Más información

ID de Registro: 30832
Identificador DC: http://oa.upm.es/30832/
Identificador OAI: oai:oa.upm.es:30832
Identificador DOI: 10.1186/1556-276X-9-441
URL Oficial: http://www.nanoscalereslett.com/content/pdf/1556-276X-9-441.pdf
Depositado por: Memoria Investigacion
Depositado el: 11 Abr 2015 11:22
Ultima Modificación: 11 Abr 2015 11:22
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