Brain-wide slowing of spontaneous alpha rhythms in mild cognitive impairment

Garcés, Pilar; Vicente, Raúl; Wibral, Michael; Pineda Pardo, José Ángel; López García, María Eugenia; Aurtenetxe, Sara; Marcos, Alberto; Andrés, María Emiliana de; Yus, Miguel; Sancho, Miguel; Maestú, Fernando y Fernández, Alberto (2013). Brain-wide slowing of spontaneous alpha rhythms in mild cognitive impairment. "Frontiers in Aging Neuroscience", v. 5 ; pp. 1-7. ISSN 1663-4365. https://doi.org/10.3389/fnagi.2013.00100.

Descripción

Título: Brain-wide slowing of spontaneous alpha rhythms in mild cognitive impairment
Autor/es:
  • Garcés, Pilar
  • Vicente, Raúl
  • Wibral, Michael
  • Pineda Pardo, José Ángel
  • López García, María Eugenia
  • Aurtenetxe, Sara
  • Marcos, Alberto
  • Andrés, María Emiliana de
  • Yus, Miguel
  • Sancho, Miguel
  • Maestú, Fernando
  • Fernández, Alberto
Tipo de Documento: Artículo
Título de Revista/Publicación: Frontiers in Aging Neuroscience
Fecha: Diciembre 2013
Volumen: 5
Materias:
Palabras Clave Informales: Mild cognitive impairment, magnetoencephalography, alpha peak, slowing, hippocampal volume
Escuela: Centro de Tecnología Biomédica (CTB) (UPM)
Departamento: Aeronaves y Vehículos Espaciales
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

The neurophysiological changes associated with Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) include an increase in low frequency activity, as measured with electroencephalography or magnetoencephalography (MEG). A relevant property of spectral measures is the alpha peak, which corresponds to the dominant alpha rhythm. Here we studied the spatial distribution of MEG resting state alpha peak frequency and amplitude values in a sample of 27 MCI patients and 24 age-matched healthy controls. Power spectra were reconstructed in source space with linearly constrained minimum variance beamformer. Then, 88 Regions of Interest (ROIs) were defined and an alpha peak per ROI and subject was identified. Statistical analyses were performed at every ROI, accounting for age, sex and educational level. Peak frequency was significantly decreased (p < 0.05) in MCIs in many posterior ROIs. The average peak frequency over all ROIs was 9.68 ± 0.71 Hz for controls and 9.05 ± 0.90 Hz for MCIs and the average normalized amplitude was (2.57 ± 0.59)·10−2 for controls and (2.70 ± 0.49)·10−2 for MCIs. Age and gender were also found to play a role in the alpha peak, since its frequency was higher in females than in males in posterior ROIs and correlated negatively with age in frontal ROIs. Furthermore, we examined the dependence of peak parameters with hippocampal volume, which is a commonly used marker of early structural AD-related damage. Peak frequency was positively correlated with hippocampal volume in many posterior ROIs. Overall, these findings indicate a pathological alpha slowing in MCI.

Más información

ID de Registro: 31183
Identificador DC: http://oa.upm.es/31183/
Identificador OAI: oai:oa.upm.es:31183
Identificador DOI: 10.3389/fnagi.2013.00100
URL Oficial: http://journal.frontiersin.org/article/10.3389/fnagi.2013.00100/abstract
Depositado por: Memoria Investigacion
Depositado el: 18 Abr 2015 10:30
Ultima Modificación: 18 Abr 2015 10:30
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