White matter damage disorganizes brain functional networks in amnestic mild cognitive impairment

Pineda Pardo, José Ángel; Garcés, Pilar; López García, María Eugenia; Aurtenetxe, Sara; Cuesta, Pablo; Marcos, Alberto; Montejo Carrasco, Pedro; Yus, Miguel; Hernández Tamames, J.A.; Pozo Guerrero, Francisco del; Becker, James T. y Maestú, Fernando (2014). White matter damage disorganizes brain functional networks in amnestic mild cognitive impairment. "Brain Connectivity", v. 4 (n. 5); pp. 312-322. ISSN 2158-0014.

Descripción

Título: White matter damage disorganizes brain functional networks in amnestic mild cognitive impairment
Autor/es:
  • Pineda Pardo, José Ángel
  • Garcés, Pilar
  • López García, María Eugenia
  • Aurtenetxe, Sara
  • Cuesta, Pablo
  • Marcos, Alberto
  • Montejo Carrasco, Pedro
  • Yus, Miguel
  • Hernández Tamames, J.A.
  • Pozo Guerrero, Francisco del
  • Becker, James T.
  • Maestú, Fernando
Tipo de Documento: Artículo
Título de Revista/Publicación: Brain Connectivity
Fecha: Junio 2014
Volumen: 4
Materias:
Palabras Clave Informales: Diffusion tensor image; graph theory; magnetoencephalography; mild cognitive impairment; multimodal integration; phase synchronization
Escuela: Centro de Tecnología Biomédica (CTB) (UPM)
Departamento: Aeronaves y Vehículos Espaciales
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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URL Oficial: http://online.liebertpub.com/doi/abs/10.1089/brain.2013.0208

Resumen

Although progressive functional brain network disruption has been one of the hallmarks of Alzheimer?s Dis- ease, little is known about the origin of this functional impairment that underlies cognitive symptoms. We in- vestigated how the loss of white matter (WM) integrity disrupts the organization of the functional networks at different frequency bands. The analyses were performed in a sample of healthy elders and mild cognitive im- pairment (MCI) subjects. Spontaneous brain magnetic activity (measured with magnetoencephalography) was characterized with phase synchronization analysis, and graph theory was applied to the functional networks. We identified WM areas (using diffusion weighted magnetic resonance imaging) that showed a statistical de- pendence between the fractional anisotropy and the graph metrics. These regions are part of an episodic mem- ory network and were also related to cognitive functions. Our data support the hypothesis that disruption of the anatomical networks influences the organization at the functional level resulting in the prodromal dementia syndrome of MCI.

Más información

ID de Registro: 33512
Identificador DC: http://oa.upm.es/33512/
Identificador OAI: oai:oa.upm.es:33512
Depositado por: Memoria Investigacion
Depositado el: 12 Abr 2015 13:16
Ultima Modificación: 01 Jul 2015 22:56
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