White matter damage disorganizes brain functional networks in amnestic mild cognitive impairment

Pineda Pardo, José Ángel and Garcés, Pilar and López García, María Eugenia and Aurtenetxe, Sara and Cuesta, Pablo and Marcos, Alberto and Montejo Carrasco, Pedro and Yus, Miguel and Hernández Tamames, J.A. and Pozo Guerrero, Francisco del and Becker, James T. and Maestú, Fernando (2014). White matter damage disorganizes brain functional networks in amnestic mild cognitive impairment. "Brain Connectivity", v. 4 (n. 5); pp. 312-322. ISSN 2158-0014. https://doi.org/10.1089/brain.2013.0208.

Description

Title: White matter damage disorganizes brain functional networks in amnestic mild cognitive impairment
Author/s:
  • Pineda Pardo, José Ángel
  • Garcés, Pilar
  • López García, María Eugenia
  • Aurtenetxe, Sara
  • Cuesta, Pablo
  • Marcos, Alberto
  • Montejo Carrasco, Pedro
  • Yus, Miguel
  • Hernández Tamames, J.A.
  • Pozo Guerrero, Francisco del
  • Becker, James T.
  • Maestú, Fernando
Item Type: Article
Título de Revista/Publicación: Brain Connectivity
Date: June 2014
ISSN: 2158-0014
Volume: 4
Subjects:
Freetext Keywords: Diffusion tensor image; graph theory; magnetoencephalography; mild cognitive impairment; multimodal integration; phase synchronization
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Aeronaves y Vehículos Espaciales
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Although progressive functional brain network disruption has been one of the hallmarks of Alzheimer?s Dis- ease, little is known about the origin of this functional impairment that underlies cognitive symptoms. We in- vestigated how the loss of white matter (WM) integrity disrupts the organization of the functional networks at different frequency bands. The analyses were performed in a sample of healthy elders and mild cognitive im- pairment (MCI) subjects. Spontaneous brain magnetic activity (measured with magnetoencephalography) was characterized with phase synchronization analysis, and graph theory was applied to the functional networks. We identified WM areas (using diffusion weighted magnetic resonance imaging) that showed a statistical de- pendence between the fractional anisotropy and the graph metrics. These regions are part of an episodic mem- ory network and were also related to cognitive functions. Our data support the hypothesis that disruption of the anatomical networks influences the organization at the functional level resulting in the prodromal dementia syndrome of MCI.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainPSI2012-38375C03-01UnspecifiedUnspecifiedUnspecified
Government of Spain(PSI2009-14415C03-01UnspecifiedUnspecifiedUnspecified
Government of SpainAP2010-1317UnspecifiedUnspecifiedUnspecified
Government of SpainFPU AP-2008-00175UnspecifiedUnspecifiedUnspecified

More information

Item ID: 33512
DC Identifier: http://oa.upm.es/33512/
OAI Identifier: oai:oa.upm.es:33512
DOI: 10.1089/brain.2013.0208
Official URL: http://online.liebertpub.com/doi/abs/10.1089/brain.2013.0208
Deposited by: Memoria Investigacion
Deposited on: 12 Apr 2015 13:16
Last Modified: 06 May 2019 07:55
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