The default mode network is functionally and structurally disrupted in amnestic mild cognitive impairment — a bimodal MEG–DTI study

Garcés, Pilar and Pineda Pardo, José Ángel and Canuet, Leonides and Aurtenetxe, Sara and López García, María Eugenia and Marcos, Alberto and Yus, Miguel and Llanero Luque, Marcos and Pozo Guerrero, Francisco del and Sancho, Miguel and Maestú, Fernando (2014). The default mode network is functionally and structurally disrupted in amnestic mild cognitive impairment — a bimodal MEG–DTI study. "NeuroImage: Clinical", v. 6 ; pp. 214-221. ISSN 2213-1582. https://doi.org/10.1016/j.nicl.2014.09.004.

Description

Title: The default mode network is functionally and structurally disrupted in amnestic mild cognitive impairment — a bimodal MEG–DTI study
Author/s:
  • Garcés, Pilar
  • Pineda Pardo, José Ángel
  • Canuet, Leonides
  • Aurtenetxe, Sara
  • López García, María Eugenia
  • Marcos, Alberto
  • Yus, Miguel
  • Llanero Luque, Marcos
  • Pozo Guerrero, Francisco del
  • Sancho, Miguel
  • Maestú, Fernando
Item Type: Article
Título de Revista/Publicación: NeuroImage: Clinical
Date: 2014
ISSN: 2213-1582
Volume: 6
Subjects:
Freetext Keywords: Default mode network; Mild cognitive impairment; Magnetoencephalography; Functional connectivity; Alpha band; Structural connectivity; Diffusion tensor imaging; Tractography
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Aeronaves y Vehículos Espaciales
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Over the past years, several studies on Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) have reported Default Mode Network (DMN) deficits. This network is attracting increasing interest in the AD community, as it seems to play an important role in cognitive functioning and in beta amyloid deposition. Attention has been particularly drawn to how different DMN regions are connected using functional or structural connectivity. To this end, most studies have used functional Magnetic Resonance Imaging (fMRI), Positron Emission Tomography (PET) or Diffusion Tensor Imaging (DTI). In this study we evaluated (1) functional connectivity from resting state magnetoencephalography (MEG) and (2) structural connectivity from DTI in 26 MCI patients and 31 age-matched controls. Compared to controls, the DMN in the MCI group was functionally disrupted in the alpha band, while no differences were found for delta, theta, beta and gamma frequency bands. In addition, structural disconnection could be assessed through a decreased fractional anisotropy along tracts connecting different DMN regions. This suggests that the DMN functional and anatomical disconnection could represent a core feature of MCI.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainPSI2009-14415-C03-01UnspecifiedUnspecifiedUnspecified
Government of SpainPSI2012-38375-C03-01UnspecifiedUnspecifiedUnspecified
Government of SpainAP2010-1317UnspecifiedUnspecifiedUnspecified

More information

Item ID: 33514
DC Identifier: http://oa.upm.es/33514/
OAI Identifier: oai:oa.upm.es:33514
DOI: 10.1016/j.nicl.2014.09.004
Official URL: http://www.sciencedirect.com/science/article/pii/S2213158214001405
Deposited by: Memoria Investigacion
Deposited on: 11 Apr 2015 11:39
Last Modified: 06 May 2019 07:58
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