The default mode network is functionally and structurally disrupted in amnestic mild cognitive impairment — a bimodal MEG–DTI study

Garcés, Pilar; Pineda Pardo, José Ángel; Canuet, Leonides; Aurtenetxe, Sara; López García, María Eugenia; Marcos, Alberto; Yus, Miguel; Llanero Luque, Marcos; Pozo Guerrero, Francisco del; Sancho, Miguel y Maestú, Fernando (2014). The default mode network is functionally and structurally disrupted in amnestic mild cognitive impairment — a bimodal MEG–DTI study. "NeuroImage: Clinical", v. 6 ; pp. 214-221. ISSN 2213-1582.

Descripción

Título: The default mode network is functionally and structurally disrupted in amnestic mild cognitive impairment — a bimodal MEG–DTI study
Autor/es:
  • Garcés, Pilar
  • Pineda Pardo, José Ángel
  • Canuet, Leonides
  • Aurtenetxe, Sara
  • López García, María Eugenia
  • Marcos, Alberto
  • Yus, Miguel
  • Llanero Luque, Marcos
  • Pozo Guerrero, Francisco del
  • Sancho, Miguel
  • Maestú, Fernando
Tipo de Documento: Artículo
Título de Revista/Publicación: NeuroImage: Clinical
Fecha: 2014
Volumen: 6
Materias:
Palabras Clave Informales: Default mode network; Mild cognitive impairment; Magnetoencephalography; Functional connectivity; Alpha band; Structural connectivity; Diffusion tensor imaging; Tractography
Escuela: Centro de Tecnología Biomédica (CTB) (UPM)
Departamento: Aeronaves y Vehículos Espaciales
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Over the past years, several studies on Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) have reported Default Mode Network (DMN) deficits. This network is attracting increasing interest in the AD community, as it seems to play an important role in cognitive functioning and in beta amyloid deposition. Attention has been particularly drawn to how different DMN regions are connected using functional or structural connectivity. To this end, most studies have used functional Magnetic Resonance Imaging (fMRI), Positron Emission Tomography (PET) or Diffusion Tensor Imaging (DTI). In this study we evaluated (1) functional connectivity from resting state magnetoencephalography (MEG) and (2) structural connectivity from DTI in 26 MCI patients and 31 age-matched controls. Compared to controls, the DMN in the MCI group was functionally disrupted in the alpha band, while no differences were found for delta, theta, beta and gamma frequency bands. In addition, structural disconnection could be assessed through a decreased fractional anisotropy along tracts connecting different DMN regions. This suggests that the DMN functional and anatomical disconnection could represent a core feature of MCI.

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ID de Registro: 33514
Identificador DC: http://oa.upm.es/33514/
Identificador OAI: oai:oa.upm.es:33514
Depositado por: Memoria Investigacion
Depositado el: 11 Abr 2015 11:39
Ultima Modificación: 11 Abr 2015 11:39
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