Random positions of dendritic spines in human cerebral cortex

Morales Del Olmo, Juan and Benavides Piccione, Ruth and Dar, Mor and Fernaud Espinosa, Isabel and Rodríguez, Ángel and Antón Sánchez, Laura and Bielza Lozoya, Maria Concepcion and Larrañaga Múgica, Pedro and Felipe Oroquieta, Javier de and Yuste, Rafael (2014). Random positions of dendritic spines in human cerebral cortex. "Journal of Neuroscience", v. 34 (n. 30); pp. 10078-10084. ISSN 0270-6474. https://doi.org/10.1523/JNEUROSCI.1085-14.2014.

Description

Title: Random positions of dendritic spines in human cerebral cortex
Author/s:
  • Morales Del Olmo, Juan
  • Benavides Piccione, Ruth
  • Dar, Mor
  • Fernaud Espinosa, Isabel
  • Rodríguez, Ángel
  • Antón Sánchez, Laura
  • Bielza Lozoya, Maria Concepcion
  • Larrañaga Múgica, Pedro
  • Felipe Oroquieta, Javier de
  • Yuste, Rafael
Item Type: Article
Título de Revista/Publicación: Journal of Neuroscience
Date: July 2014
ISSN: 0270-6474
Volume: 34
Subjects:
Freetext Keywords: Fourier; Lucifer; Intracellular injections; Pyramidal cells; Spatial distribution
Faculty: E.T.S. de Ingenieros Informáticos (UPM)
Department: Inteligencia Artificial
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Dendritic spines establish most excitatory synapses in the brain and are located in Purkinje cell’s dendrites along helical paths, perhaps maximizing the probability to contact different axons. To test whether spine helixes also occur in neocortex, we reconstructed >500 dendritic segments from adult human cortex obtained from autopsies. With Fourier analysis and spatial statistics, we analyzed spine position along apical and basal dendrites of layer 3 pyramidal neurons from frontal, temporal, and cingulate cortex. Although we occasionally detected helical positioning, for the great majority of dendrites we could not reject the null hypothesis of spatial randomness in spine locations, either in apical or basal dendrites, in neurons of different cortical areas or among spines of different volumes and lengths. We conclude that in adult human neocortex spine positions are mostly random. We discuss the relevance of these results for spine formation and plasticity and their functional impact for cortical circuits.

More information

Item ID: 35440
DC Identifier: http://oa.upm.es/35440/
OAI Identifier: oai:oa.upm.es:35440
DOI: 10.1523/JNEUROSCI.1085-14.2014
Official URL: http://www.jneurosci.org/content/34/30/10078
Deposited by: Memoria Investigacion
Deposited on: 11 Jun 2015 12:39
Last Modified: 18 Jan 2017 09:37
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