Drug polyconsumption is associated with increased synchronization of brain electrical-activity at rest and in a counting task

Coullaut-Valera, Rafael; Arbaiza Díaz del Río, Iria; Bajo Breton, Ricardo; Arrúe Ruiloba, Ricardo de; López García, María Eugenia; Coullaut-Valera, Juan; Correas Marín, Ángeles; López Sanz, David; Maestú Unturbe, Fernando y Papo, David (2014). Drug polyconsumption is associated with increased synchronization of brain electrical-activity at rest and in a counting task. "International Journal of Neural Systems", v. 24 (n. 1); pp. 1-13. ISSN 0129-0657. https://doi.org/10.1142/S0129065714500051.

Descripción

Título: Drug polyconsumption is associated with increased synchronization of brain electrical-activity at rest and in a counting task
Autor/es:
  • Coullaut-Valera, Rafael
  • Arbaiza Díaz del Río, Iria
  • Bajo Breton, Ricardo
  • Arrúe Ruiloba, Ricardo de
  • López García, María Eugenia
  • Coullaut-Valera, Juan
  • Correas Marín, Ángeles
  • López Sanz, David
  • Maestú Unturbe, Fernando
  • Papo, David
Tipo de Documento: Artículo
Título de Revista/Publicación: International Journal of Neural Systems
Fecha: Febrero 2014
Volumen: 24
Materias:
Palabras Clave Informales: Addiction; polydrug use; EEG; resting state; synchronization; functional connectivity
Escuela: Centro de Tecnología Biomédica (CTB) (UPM)
Departamento: Tecnología Fotónica y Bioingeniería
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Drug abusers typically consume not just one but several types of drugs, starting from alcohol and marijuana consumption, and then dramatically lapsing into addiction to harder drugs, such as cocaine, heroin, or amphetamine. The brain of drug abusers presents various structural and neurophysiological abnormalities, some of which may predate drug consumption onset. However, how these changes translate into modifications in functional brain connectivity is still poorly understood. To characterize functional connectivity patterns, we recorded Electroencephalogram (EEG) activity from 21 detoxified drug abusers and 20 age-matched control subjects performing a simple counting task and at rest activity. To evaluate the cortical brain connectivity network we applied the Synchronization Likelihood algorithm. The results showed that drug abusers had higher synchronization levels at low frequencies, mainly in the θ band (4–8 Hz) between frontal and posterior cortical regions. During the counting task, patients showed increased synchronization in the β (14–35 Hz), and γ (35–45 Hz) frequency bands, in fronto-posterior and interhemispheric temporal regions. Taken together 'slow-down' at rest and task-related 'over-exertion' could indicate that the brain of drug abusers is suffering from a premature form of ageing. Future studies will clarify whether this condition can be reversed following prolonged periods of abstinence.

Más información

ID de Registro: 35569
Identificador DC: http://oa.upm.es/35569/
Identificador OAI: oai:oa.upm.es:35569
Identificador DOI: 10.1142/S0129065714500051
URL Oficial: http://www.worldscientific.com/doi/abs/10.1142/S0129065714500051
Depositado por: Memoria Investigacion
Depositado el: 24 Abr 2017 16:06
Ultima Modificación: 24 Abr 2017 16:06
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