Alpha-band hypersynchronization in progressive mild cognitive impairment. A magnetoencephalography study

López García, María Eugenia and Bruña Fernandez, Ricardo and Aurtenetxe, Sara and Pineda Pardo, José Ángel and Marcos, Alberto and Arrazola, Juan and Reinoso García, Ana Isabel and Montejo Carrasco, Pedro and Bajo Breton, Ricardo and Maestú Unturbe, Fernando (2014). Alpha-band hypersynchronization in progressive mild cognitive impairment. A magnetoencephalography study. "The Journal of Neuroscience", v. 34 (n. 44); pp. 14551-14559. ISSN 0270-6474. https://doi.org/10.1523/JNEUROSCI.0964-14.2014.

Description

Title: Alpha-band hypersynchronization in progressive mild cognitive impairment. A magnetoencephalography study
Author/s:
  • López García, María Eugenia
  • Bruña Fernandez, Ricardo
  • Aurtenetxe, Sara
  • Pineda Pardo, José Ángel
  • Marcos, Alberto
  • Arrazola, Juan
  • Reinoso García, Ana Isabel
  • Montejo Carrasco, Pedro
  • Bajo Breton, Ricardo
  • Maestú Unturbe, Fernando
Item Type: Article
Título de Revista/Publicación: The Journal of Neuroscience
Date: 29 October 2014
ISSN: 0270-6474
Volume: 34
Subjects:
Freetext Keywords: alpha band; anterior cingulate; functional connectivity; MEG; mild cognitive impairment; phase locking value
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

People with mild cognitive impairment (MCI) show a high risk to develop Alzheimer?s disease (AD; Petersen et al., 2001). Nonetheless, there is a lack of studies about how functional connectivity patterns may distinguish between progressive (pMCI) and stable (sMCI) MCI patients. To examine whether there were differences in functional connectivity between groups, MEG eyes-closed recordings from 30 sMCI and 19 pMCI subjects were compared. The average conversion time of pMCI was 1 year, so they were considered as fast converters. To this end, functional connectivity in different frequency bands was assessed with phase locking value in source space. Then the significant differences between both groups were correlated with neuropsychological scores and entorhinal, parahippocampal, and hippocampal volumes. Both groups did not differ in age, gender, or educational level. pMCI patients obtained lower scores in episodic and semantic memory and also in executive functioning. At the structural level, there were no differences in hippocampal volume, although some were found in left entorhinal volume between both groups. Additionally, pMCI patients exhibit a higher synchronization in the alpha band between the right anterior cingulate and temporo-occipital regions than sMCI subjects. This hypersynchronization was inversely correlated with cognitive performance, both hippocampal volumes, and left entorhinal volume. The increase in phase synchro- nization between the right anterior cingulate and temporo-occipital areas may be predictive of conversion from MCI to AD.

More information

Item ID: 35693
DC Identifier: http://oa.upm.es/35693/
OAI Identifier: oai:oa.upm.es:35693
DOI: 10.1523/JNEUROSCI.0964-14.2014
Official URL: https://www.ncbi.nlm.nih.gov/pubmed/25355209
Deposited by: Memoria Investigacion
Deposited on: 25 Apr 2017 15:31
Last Modified: 25 Apr 2017 15:31
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