Alpha-band hypersynchronization in progressive mild cognitive impairment. A magnetoencephalography study

López García, María Eugenia; Bruña Fernandez, Ricardo; Aurtenetxe, Sara; Pineda Pardo, José Ángel; Marcos, Alberto; Arrazola, Juan; Reinoso García, Ana Isabel; Montejo Carrasco, Pedro; Bajo Breton, Ricardo y Maestú Unturbe, Fernando (2014). Alpha-band hypersynchronization in progressive mild cognitive impairment. A magnetoencephalography study. "The Journal of Neuroscience", v. 34 (n. 44); pp. 14551-14559. ISSN 0270-6474. https://doi.org/10.1523/JNEUROSCI.0964-14.2014.

Descripción

Título: Alpha-band hypersynchronization in progressive mild cognitive impairment. A magnetoencephalography study
Autor/es:
  • López García, María Eugenia
  • Bruña Fernandez, Ricardo
  • Aurtenetxe, Sara
  • Pineda Pardo, José Ángel
  • Marcos, Alberto
  • Arrazola, Juan
  • Reinoso García, Ana Isabel
  • Montejo Carrasco, Pedro
  • Bajo Breton, Ricardo
  • Maestú Unturbe, Fernando
Tipo de Documento: Artículo
Título de Revista/Publicación: The Journal of Neuroscience
Fecha: 29 Octubre 2014
Volumen: 34
Materias:
Palabras Clave Informales: alpha band; anterior cingulate; functional connectivity; MEG; mild cognitive impairment; phase locking value
Escuela: Centro de Tecnología Biomédica (CTB) (UPM)
Departamento: Otro
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

People with mild cognitive impairment (MCI) show a high risk to develop Alzheimer?s disease (AD; Petersen et al., 2001). Nonetheless, there is a lack of studies about how functional connectivity patterns may distinguish between progressive (pMCI) and stable (sMCI) MCI patients. To examine whether there were differences in functional connectivity between groups, MEG eyes-closed recordings from 30 sMCI and 19 pMCI subjects were compared. The average conversion time of pMCI was 1 year, so they were considered as fast converters. To this end, functional connectivity in different frequency bands was assessed with phase locking value in source space. Then the significant differences between both groups were correlated with neuropsychological scores and entorhinal, parahippocampal, and hippocampal volumes. Both groups did not differ in age, gender, or educational level. pMCI patients obtained lower scores in episodic and semantic memory and also in executive functioning. At the structural level, there were no differences in hippocampal volume, although some were found in left entorhinal volume between both groups. Additionally, pMCI patients exhibit a higher synchronization in the alpha band between the right anterior cingulate and temporo-occipital regions than sMCI subjects. This hypersynchronization was inversely correlated with cognitive performance, both hippocampal volumes, and left entorhinal volume. The increase in phase synchro- nization between the right anterior cingulate and temporo-occipital areas may be predictive of conversion from MCI to AD.

Más información

ID de Registro: 35693
Identificador DC: http://oa.upm.es/35693/
Identificador OAI: oai:oa.upm.es:35693
Identificador DOI: 10.1523/JNEUROSCI.0964-14.2014
URL Oficial: https://www.ncbi.nlm.nih.gov/pubmed/25355209
Depositado por: Memoria Investigacion
Depositado el: 25 Abr 2017 15:31
Ultima Modificación: 25 Abr 2017 15:31
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