Alt a 1 from Alternaria interacts with PR5 thaumatin-like proteins

Gomez Casado, Cristina and Murua Garcia, Amaya and Garrido Arandia, M. and González-Melendi, Pablo and Sánchez-Monge Laguna de Rins, Rosa and Barber, Domingo and Fernandez Pacios, Luis and Diaz Perales, Araceli (2014). Alt a 1 from Alternaria interacts with PR5 thaumatin-like proteins. "Febs Letters", v. 588 (n. 9); pp. 1501-1508. ISSN 0014-5793. https://doi.org/10.1016/j.febslet.2014.02.044.

Description

Title: Alt a 1 from Alternaria interacts with PR5 thaumatin-like proteins
Author/s:
  • Gomez Casado, Cristina
  • Murua Garcia, Amaya
  • Garrido Arandia, M.
  • González-Melendi, Pablo
  • Sánchez-Monge Laguna de Rins, Rosa
  • Barber, Domingo
  • Fernandez Pacios, Luis
  • Diaz Perales, Araceli
Item Type: Article
Título de Revista/Publicación: Febs Letters
Date: May 2014
ISSN: 0014-5793
Volume: 588
Subjects:
Faculty: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Department: Biotecnología - Biología Vegetal
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Alt a 1 is a protein found in Alternaria alternata spores related to virulence and pathogenicity and considered to be responsible for chronic asthma in children. We found that spores of Alternaria inoculated on the outer surface of kiwifruits did not develop hyphae. Nevertheless, the expression of Alt a 1 gene was upregulated, and the protein was detected in the pulp where it co-localized with kiwi PR5. Pull-down assays demonstrated experimentally that the two proteins interact in such a way that Alt a 1 inhibits the enzymatic activity of PR5. These results are relevant not only for plant defense, but also for human health as patients with chronic asthma could suffer from an allergic reaction when they eat fruit contaminated with Alternaria.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainBIO2009-07050UnspecifiedUnspecifiedUnspecified

More information

Item ID: 35969
DC Identifier: http://oa.upm.es/35969/
OAI Identifier: oai:oa.upm.es:35969
DOI: 10.1016/j.febslet.2014.02.044
Official URL: http://www.sciencedirect.com/science/article/pii/S0014579314001641
Deposited by: Memoria Investigacion
Deposited on: 01 Jul 2015 16:16
Last Modified: 10 Jun 2019 07:21
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