Effects of alprazolam on cortical activity and tremors in patients with essential tremor

Ibañez Pereda, Jaime and González de la Aleja, Jesús and Gallego Juárez, Juan Antonio and Romero Muñoz, Juan Pablo and Saiz-Díaz, Rosana A. and Benito León, Julián and Rocón de Lima, Eduardo (2014). Effects of alprazolam on cortical activity and tremors in patients with essential tremor. "Plos One", v. 9 (n. 3); pp. 1-8. ISSN 1932-6203. https://doi.org/10.1371/journal.pone.0093159.

Description

Title: Effects of alprazolam on cortical activity and tremors in patients with essential tremor
Author/s:
  • Ibañez Pereda, Jaime
  • González de la Aleja, Jesús
  • Gallego Juárez, Juan Antonio
  • Romero Muñoz, Juan Pablo
  • Saiz-Díaz, Rosana A.
  • Benito León, Julián
  • Rocón de Lima, Eduardo
Item Type: Article
Título de Revista/Publicación: Plos One
Date: 25 March 2014
Volume: 9
Subjects:
Faculty: Centro de Automática y Robótica (CAR) UPM-CSIC
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Essential tremor (ET) is characterised by postural and action tremors with a frequency of 4-12 Hz. Previous studies suggest that the tremor activity originates in the cerebello-thalamocortical pathways. Alprazolam is a short-acting benzodiazepine that attenuates tremors in ET. The mechanisms that mediate the therapeutic action of alprazolam are unknown; however, in healthy subjects, benzodiazepines increase cortical beta activity. In this study, we investigated the effect of alprazolam both on beta and tremor-related cortical activity and on alterations in tremor presentation in ET patients. Therefore, we characterised the dynamics of tremor and cortical activity in ET patients after alprazolam intake.

More information

Item ID: 38718
DC Identifier: http://oa.upm.es/38718/
OAI Identifier: oai:oa.upm.es:38718
DOI: 10.1371/journal.pone.0093159
Official URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093159
Deposited by: Memoria Investigacion
Deposited on: 01 Apr 2017 08:47
Last Modified: 01 Apr 2017 08:47
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