MEG spectral analysis in subtypes of mild cognitive impairment

López García, María Eugenia and Cuesta Prieto, Pablo and Garcés López, Mª Pilar and Castellanos, Nazareth and Aurtenetxe, Sara and Bajo Breton, Ricardo and Marcos Dolado, Alberto and Delgado, M. L. and Montejo, P. and López Pantoja, J. L. and Maestú Unturbe, Fernando and Fernández Lucas, Alberto (2014). MEG spectral analysis in subtypes of mild cognitive impairment. "AGE" ; pp. 1-18. ISSN 0161-9152. https://doi.org/10.1007/s11357-014-9624-5.

Description

Title: MEG spectral analysis in subtypes of mild cognitive impairment
Author/s:
  • López García, María Eugenia
  • Cuesta Prieto, Pablo
  • Garcés López, Mª Pilar
  • Castellanos, Nazareth
  • Aurtenetxe, Sara
  • Bajo Breton, Ricardo
  • Marcos Dolado, Alberto
  • Delgado, M. L.
  • Montejo, P.
  • López Pantoja, J. L.
  • Maestú Unturbe, Fernando
  • Fernández Lucas, Alberto
Item Type: Article
Título de Revista/Publicación: AGE
Date: 23 January 2014
ISSN: 0161-9152
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Mild cognitive impairment (MCI) has been described as an intermediate stage between normal aging and dementia. Previous studies characterized the alterations of brain oscillatory activity at this stage, but little is known about the differences between single and multidomain amnestic MCI patients. In order to study the patterns of oscillatory magnetic activity in amnestic MCI subtypes, a total of 105 subjects underwent an eyes-closed resting-state magnetoencephalographic recording: 36 healthy controls, 33 amnestic single domain MCIs (a-sd-MCI), and 36 amnestic multidomain MCIs (a-md-MCI). Relative power values were calculated and compared among groups. Subsequently, relative power values were correlated with neuropsychological tests scores and hippocampal volumes. Both MCI groups showed an increase in relative power in lower frequency bands (delta and theta frequency ranges) and a decrease in power values in higher frequency bands (alpha and beta frequency ranges), as compared with the control group. More importantly, clear differences emerged from the comparison between the two amnestic MCI subtypes. The a-md-MCI group showed a significant power increase within delta and theta ranges and reduced relative power within alpha and beta ranges. Such pattern correlated with the neuropsychological performance, indicating that the a-md-MCI subtype is associated not only with a "slowing" of the spectrum but also with a poorer cognitive status. These results suggest that a-md-MCI patients are characterized by a brain activity profile that is closer to that observed in Alzheimer disease. Therefore, it might be hypothesized that the likelihood of conversion to dementia would be higher within this subtype.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainPSI2009-14415-C03-01UnspecifiedUnspecifiedUnspecified
Government of SpainPSI2012-38375-C03-01UnspecifiedUnspecifiedUnspecified

More information

Item ID: 38811
DC Identifier: http://oa.upm.es/38811/
OAI Identifier: oai:oa.upm.es:38811
DOI: 10.1007/s11357-014-9624-5
Official URL: https://link.springer.com/journal/11357
Deposited by: Memoria Investigacion
Deposited on: 25 Apr 2017 17:05
Last Modified: 12 Jun 2019 08:07
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