Identification of Novel Components of the Unfolded Protein Response in Arabidopsis

Hossain, Md. Amir; Henríquez-Valencia, Carlos; Gómez-Páez, Marcela; Medina Alcazar, Joaquin; Orellana, Ariel; Vicente Carbajosa, Jesus y Zouhar, Jan (2016). Identification of Novel Components of the Unfolded Protein Response in Arabidopsis. "Frontiers in Plant Sciences" ; ISSN 1664-462X. https://doi.org/10.3389/fpls.2016.00650.

Descripción

Título: Identification of Novel Components of the Unfolded Protein Response in Arabidopsis
Autor/es:
  • Hossain, Md. Amir
  • Henríquez-Valencia, Carlos
  • Gómez-Páez, Marcela
  • Medina Alcazar, Joaquin
  • Orellana, Ariel
  • Vicente Carbajosa, Jesus
  • Zouhar, Jan
Tipo de Documento: Artículo
Título de Revista/Publicación: Frontiers in Plant Sciences
Fecha: 12 Mayo 2016
Materias:
Palabras Clave Informales: Unfolded Protein Response, endoplasmic reticulum, transcription factors, abiotic stress, Arabidopsis
Escuela: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Departamento: Biotecnología - Biología Vegetal
Grupo Investigación UPM: Redes Reguladoras del Desarrollo y Respuesta a Estrés en Plantas
Licencias Creative Commons: Reconocimiento

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Resumen

Unfavorable environmental and developmental conditions may cause disturbances in protein folding in the endoplasmic reticulum (ER) that are recognized and counteracted by components of the Unfolded Protein Response (UPR) signaling pathways. The early cellular responses include transcriptional changes to increase the folding and processing capacity of the ER. In this study, we systematically screened a collection of inducible transgenic Arabidopsis plants expressing a library of transcription factors for resistance toward UPR-inducing chemicals. We identified 23 candidate genes that may function as novel regulators of the UPR and of which only three genes (bZIP10, TBF1, and NF-YB3) were previously associated with the UPR. The putative role of identified candidate genes in the UPR signaling is supported by favorable expression patterns in both developmental and stress transcriptional analyses. We demonstrated that WRKY75 is a genuine regulator of the ER-stress cellular responses as its expression was found to be directly responding to ER stress-inducing chemicals. In addition, transgenic Arabidopsis plants expressing WRKY75 showed resistance toward salt stress, connecting abiotic and ER-stress responses.

Proyectos asociados

TipoCódigoAcrónimoResponsableTítulo
FP7264474MERITMC-ITN - Networks for Initial Training (ITN)Metabolic Reprogramming by Induction of Transcription - FP7-PEOPLE
Gobierno de EspañaBIO2014-53181-RSin especificarSin especificarEstrés del retículo endoplásmico en plantas: respuestas y efectos

Más información

ID de Registro: 40581
Identificador DC: http://oa.upm.es/40581/
Identificador OAI: oai:oa.upm.es:40581
Identificador DOI: 10.3389/fpls.2016.00650
URL Oficial: http://journal.frontiersin.org/journal/plant-science
Depositado por: Jesus Vicente Carbajosa
Depositado el: 24 May 2016 11:22
Ultima Modificación: 14 Dic 2016 13:02
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