Identification of Novel Components of the Unfolded Protein Response in Arabidopsis

Hossain, Md. Amir and Henríquez-Valencia, Carlos and Gómez-Páez, Marcela and Medina Alcazar, Joaquin and Orellana, Ariel and Vicente Carbajosa, Jesus and Zouhar, Jan (2016). Identification of Novel Components of the Unfolded Protein Response in Arabidopsis. "Frontiers in Plant Sciences" ; ISSN 1664-462X. https://doi.org/10.3389/fpls.2016.00650.

Description

Title: Identification of Novel Components of the Unfolded Protein Response in Arabidopsis
Author/s:
  • Hossain, Md. Amir
  • Henríquez-Valencia, Carlos
  • Gómez-Páez, Marcela
  • Medina Alcazar, Joaquin
  • Orellana, Ariel
  • Vicente Carbajosa, Jesus
  • Zouhar, Jan
Item Type: Article
Título de Revista/Publicación: Frontiers in Plant Sciences
Date: 12 May 2016
ISSN: 1664-462X
Subjects:
Freetext Keywords: Unfolded Protein Response, endoplasmic reticulum, transcription factors, abiotic stress, Arabidopsis
Faculty: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Department: Biotecnología - Biología Vegetal
UPM's Research Group: Redes Reguladoras del Desarrollo y Respuesta a Estrés en Plantas
Creative Commons Licenses: Recognition

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Abstract

Unfavorable environmental and developmental conditions may cause disturbances in protein folding in the endoplasmic reticulum (ER) that are recognized and counteracted by components of the Unfolded Protein Response (UPR) signaling pathways. The early cellular responses include transcriptional changes to increase the folding and processing capacity of the ER. In this study, we systematically screened a collection of inducible transgenic Arabidopsis plants expressing a library of transcription factors for resistance toward UPR-inducing chemicals. We identified 23 candidate genes that may function as novel regulators of the UPR and of which only three genes (bZIP10, TBF1, and NF-YB3) were previously associated with the UPR. The putative role of identified candidate genes in the UPR signaling is supported by favorable expression patterns in both developmental and stress transcriptional analyses. We demonstrated that WRKY75 is a genuine regulator of the ER-stress cellular responses as its expression was found to be directly responding to ER stress-inducing chemicals. In addition, transgenic Arabidopsis plants expressing WRKY75 showed resistance toward salt stress, connecting abiotic and ER-stress responses.

Funding Projects

TypeCodeAcronymLeaderTitle
FP7264474MERITMC-ITN - Networks for Initial Training (ITN)Metabolic Reprogramming by Induction of Transcription
Government of SpainBIO2014-53181-RUnspecifiedUnspecifiedEstrés del retículo endoplásmico en plantas: respuestas y efectos

More information

Item ID: 40581
DC Identifier: http://oa.upm.es/40581/
OAI Identifier: oai:oa.upm.es:40581
DOI: 10.3389/fpls.2016.00650
Official URL: https://doi.org/10.3389/fpls.2016.00650
Deposited by: Jesus Vicente Carbajosa
Deposited on: 24 May 2016 11:22
Last Modified: 14 Mar 2019 14:18
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