Determination of selected pharmaceutical compounds in biosolids bysupported liquid extraction and gas chromatography?tandem massspectrometry

Albero, Beatriz; Sánchez Brunete, Consuelo; Miguel, Esther; Aznar Roca, Ramón y Tadeo, José L. (2014). Determination of selected pharmaceutical compounds in biosolids bysupported liquid extraction and gas chromatography?tandem massspectrometry. "Journal of Chromatography A", v. 1336 ; pp. 52-58. ISSN 0021-9673. https://doi.org/10.1016/j.chroma.2014.02.020.

Descripción

Título: Determination of selected pharmaceutical compounds in biosolids bysupported liquid extraction and gas chromatography?tandem massspectrometry
Autor/es:
  • Albero, Beatriz
  • Sánchez Brunete, Consuelo
  • Miguel, Esther
  • Aznar Roca, Ramón
  • Tadeo, José L.
Tipo de Documento: Artículo
Título de Revista/Publicación: Journal of Chromatography A
Fecha: Abril 2014
Volumen: 1336
Materias:
Escuela: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Departamento: Otro
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

In this work, an analytical method was developed for the determination of pharmaceutical drugs inbiosolids. Samples were extracted with an acidic mixture of water and acetone (1:2, v/v) and supportedliquid extraction was used for the clean-up of extracts, eluting with ethyl acetate:methanol (90:10, v/v).The compounds were determined by gas chromatography?tandem mass spectrometry using matrix-match calibration after silylation to form their t-butyldimethylsilyl derivatives. This method presentsvarious advantages, such as a fairly simple operation for the analysis of complex matrices, the use ofinexpensive glassware and low solvent volumes. Satisfactory mean recoveries were obtained with thedeveloped method ranging from 70 to 120% with relative standard deviations (RSDs) ? 13%, and limitsof detection between 0.5 and 3.6 ng g?1. The method was then successfully applied to biosolids samplescollected in Madrid and Catalonia (Spain). Eleven of the sixteen target compounds were detected in thestudied samples, at levels up to 1.1 ?g g?1(salicylic acid). Ibuprofen, caffeine, paracetamol and fenofibratewere detected in all of the samples analyzed.

Más información

ID de Registro: 40835
Identificador DC: http://oa.upm.es/40835/
Identificador OAI: oai:oa.upm.es:40835
Identificador DOI: 10.1016/j.chroma.2014.02.020
URL Oficial: http://www.sciencedirect.com/science/article/pii/S0021967314002362
Depositado por: Memoria Investigacion
Depositado el: 21 Jun 2016 15:06
Ultima Modificación: 21 Jun 2016 15:06
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