Determination of selected pharmaceutical compounds in biosolids bysupported liquid extraction and gas chromatography?tandem massspectrometry

Albero, Beatriz and Sánchez Brunete, Consuelo and Miguel, Esther and Aznar Roca, Ramón and Tadeo, José L. (2014). Determination of selected pharmaceutical compounds in biosolids bysupported liquid extraction and gas chromatography?tandem massspectrometry. "Journal of Chromatography A", v. 1336 ; pp. 52-58. ISSN 0021-9673. https://doi.org/10.1016/j.chroma.2014.02.020.

Description

Title: Determination of selected pharmaceutical compounds in biosolids bysupported liquid extraction and gas chromatography?tandem massspectrometry
Author/s:
  • Albero, Beatriz
  • Sánchez Brunete, Consuelo
  • Miguel, Esther
  • Aznar Roca, Ramón
  • Tadeo, José L.
Item Type: Article
Título de Revista/Publicación: Journal of Chromatography A
Date: April 2014
ISSN: 0021-9673
Volume: 1336
Subjects:
Faculty: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

In this work, an analytical method was developed for the determination of pharmaceutical drugs inbiosolids. Samples were extracted with an acidic mixture of water and acetone (1:2, v/v) and supportedliquid extraction was used for the clean-up of extracts, eluting with ethyl acetate:methanol (90:10, v/v).The compounds were determined by gas chromatography?tandem mass spectrometry using matrix-match calibration after silylation to form their t-butyldimethylsilyl derivatives. This method presentsvarious advantages, such as a fairly simple operation for the analysis of complex matrices, the use ofinexpensive glassware and low solvent volumes. Satisfactory mean recoveries were obtained with thedeveloped method ranging from 70 to 120% with relative standard deviations (RSDs) ? 13%, and limitsof detection between 0.5 and 3.6 ng g?1. The method was then successfully applied to biosolids samplescollected in Madrid and Catalonia (Spain). Eleven of the sixteen target compounds were detected in thestudied samples, at levels up to 1.1 ?g g?1(salicylic acid). Ibuprofen, caffeine, paracetamol and fenofibratewere detected in all of the samples analyzed.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of Spain(RTA2011-00047UnspecifiedUnspecifiedUnspecified

More information

Item ID: 40835
DC Identifier: http://oa.upm.es/40835/
OAI Identifier: oai:oa.upm.es:40835
DOI: 10.1016/j.chroma.2014.02.020
Official URL: http://www.sciencedirect.com/science/article/pii/S0021967314002362
Deposited by: Memoria Investigacion
Deposited on: 21 Jun 2016 15:06
Last Modified: 12 Jun 2019 11:56
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