A univocal definition of the neuronal soma morphology using Gaussian mixture models

Luengo Sánchez, Sergio and Bielza Lozoya, María Concepción and Benavides Piccione, Ruth and Fernaud Espinosa, Isabel and Felipe Oroquieta, Javier de and Larrañaga Múgica, Pedro María (2015). A univocal definition of the neuronal soma morphology using Gaussian mixture models. "Frontiers in Neuroanatomy", v. 9 ; pp. 1-11. ISSN 1662-5129. https://doi.org/10.3389/fnana.2015.00137.

Description

Title: A univocal definition of the neuronal soma morphology using Gaussian mixture models
Author/s:
  • Luengo Sánchez, Sergio
  • Bielza Lozoya, María Concepción
  • Benavides Piccione, Ruth
  • Fernaud Espinosa, Isabel
  • Felipe Oroquieta, Javier de
  • Larrañaga Múgica, Pedro María
Item Type: Article
Título de Revista/Publicación: Frontiers in Neuroanatomy
Date: November 2015
ISSN: 1662-5129
Volume: 9
Subjects:
Freetext Keywords: Three-dimensional soma reconstruction; Repair and segmentation; Morphology validation; Mesh comparison; Gaussian mixture model
Faculty: E.T.S. de Ingenieros Informáticos (UPM)
Department: Inteligencia Artificial
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The definition of the soma is fuzzy, as there is no clear line demarcating the soma of the labeled neurons and the origin of the dendrites and axon. Thus, the morphometric analysis of the neuronal soma is highly subjective. In this paper, we provide a mathematical definition and an automatic segmentation method to delimit the neuronal soma. We applied this method to the characterization of pyramidal cells, which are the most abundant neurons in the cerebral cortex. Since there are no benchmarks with which to compare the proposed procedure, we validated the goodness of this automatic segmentation method against manual segmentation by neuroanatomists to set up a framework for comparison. We concluded that there were no significant differences between automatically and manually segmented somata, i.e., the proposed procedure segments the neurons similarly to how a neuroanatomist does. It also provides univocal, justifiable and objective cutoffs. Thus, this study is a means of characterizing pyramidal neurons in order to objectively compare the morphometry of the somata of these neurons in different cortical areas and species.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainBFU2012-34963UnspecifiedAgencia Estatal CSIFAlteraciones neuroquímicas y microanatómicas de la corteza cerebral en la enfermedad de Alzheimer
Government of SpainCB06/05/0066UnspecifiedUnspecifiedUnspecified
Government of SpainTIN2013-41592-PUnspecifiedUniversidad Politécnica de MadridUnspecified
Madrid Regional GovernmentS2013/ICE-2845CASI - CAMUniversidad Politécnica de MadridUnspecified
FP7604102HBPUnspecifiedThe Human Brain Project

More information

Item ID: 41015
DC Identifier: http://oa.upm.es/41015/
OAI Identifier: oai:oa.upm.es:41015
DOI: 10.3389/fnana.2015.00137
Official URL: http://journal.frontiersin.org/article/10.3389/fnana.2015.00137/full
Deposited by: Memoria Investigacion
Deposited on: 10 Jan 2017 10:10
Last Modified: 06 Jun 2019 13:22
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