Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study

Houdayer, Elise; Teggi, Roberto; Velikova, Svetla; Gonzalez Rosa, Javier Jesus; Bussi, Mario; Comi, Giancarlo y Leocani, Letizia (2015). Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study. "Clinical Neurophysiology", v. 126 (n. 12); pp. 2356-2365. ISSN 1388-2457. https://doi.org/10.1016/j.clinph.2015.01.027.

Descripción

Título: Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study
Autor/es:
  • Houdayer, Elise
  • Teggi, Roberto
  • Velikova, Svetla
  • Gonzalez Rosa, Javier Jesus
  • Bussi, Mario
  • Comi, Giancarlo
  • Leocani, Letizia
Tipo de Documento: Artículo
Título de Revista/Publicación: Clinical Neurophysiology
Fecha: 16 Febrero 2015
Volumen: 126
Materias:
Palabras Clave Informales: Tinnitus, Electroencephalography, sLORETA. Resting state Event-related potentials
Escuela: Centro de Tecnología Biomédica (CTB) (UPM)
Departamento: Otro
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

To better characterize brain circuits dysfunctions in normoacousic tinnitus sufferers. Methods: 17 normoacousic chronic, unilateral high-pitched tinnitus sufferers (6 females, 43.6 ± 9.8 y.o, disease duration 22 ± 35 months) underwent a 29-channel resting-state electroencephalography (EEG – 5 min opened-eyes, 5 min closed-eyes) and auditory oddball paradigm for event-related potentials analyses (ERPs – N1, P2 and P300). Cortical 3D distribution of current source density was computed with sLORETA. Results were compared with 17 controls (9 females, 45.7 ± 15.1 y.o). Results: Eyes opened, tinnitus sufferers had lower alpha and beta sources in the left inferior parietal lobule. Eyes closed, tinnitus sufferers had decreased alpha sources in the left inferior temporal and post-central gyri, and low gamma sources in the left middle temporal gyrus. EEG data did not correlate with tinnitus sufferers’ clinical features. Subjects with tinnitus had shorter N1 and P2 latencies. P300 did not differ between groups. sLORETA solutions showed decreased sources of these ERPs in the left inferior temporal gyrus in the tinnitus group. Conclusions: We showed cortico-thalamo-cortical involvements in normoacousic tinnitus with hyperexcitability of the left auditory cortex and inferior temporal gyrus. Significance: This might reflect processes of maladaptive cortical plasticity and memory consolidation. Further validation is needed to establish the value of this tool in customizing therapeutic approach.

Más información

ID de Registro: 41080
Identificador DC: http://oa.upm.es/41080/
Identificador OAI: oai:oa.upm.es:41080
Identificador DOI: 10.1016/j.clinph.2015.01.027
URL Oficial: http://www.sciencedirect.com/science/article/pii/S1388245715000851
Depositado por: Memoria Investigacion
Depositado el: 26 Abr 2017 18:19
Ultima Modificación: 26 Abr 2017 18:19
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