Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study

Houdayer, Elise and Teggi, Roberto and Velikova, Svetla and Gonzalez Rosa, Javier Jesus and Bussi, Mario and Comi, Giancarlo and Leocani, Letizia (2015). Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study. "Clinical Neurophysiology", v. 126 (n. 12); pp. 2356-2365. ISSN 1388-2457. https://doi.org/10.1016/j.clinph.2015.01.027.

Description

Title: Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study
Author/s:
  • Houdayer, Elise
  • Teggi, Roberto
  • Velikova, Svetla
  • Gonzalez Rosa, Javier Jesus
  • Bussi, Mario
  • Comi, Giancarlo
  • Leocani, Letizia
Item Type: Article
Título de Revista/Publicación: Clinical Neurophysiology
Date: 16 February 2015
ISSN: 1388-2457
Volume: 126
Subjects:
Freetext Keywords: Tinnitus, Electroencephalography, sLORETA. Resting state Event-related potentials
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

To better characterize brain circuits dysfunctions in normoacousic tinnitus sufferers. Methods: 17 normoacousic chronic, unilateral high-pitched tinnitus sufferers (6 females, 43.6 ± 9.8 y.o, disease duration 22 ± 35 months) underwent a 29-channel resting-state electroencephalography (EEG – 5 min opened-eyes, 5 min closed-eyes) and auditory oddball paradigm for event-related potentials analyses (ERPs – N1, P2 and P300). Cortical 3D distribution of current source density was computed with sLORETA. Results were compared with 17 controls (9 females, 45.7 ± 15.1 y.o). Results: Eyes opened, tinnitus sufferers had lower alpha and beta sources in the left inferior parietal lobule. Eyes closed, tinnitus sufferers had decreased alpha sources in the left inferior temporal and post-central gyri, and low gamma sources in the left middle temporal gyrus. EEG data did not correlate with tinnitus sufferers’ clinical features. Subjects with tinnitus had shorter N1 and P2 latencies. P300 did not differ between groups. sLORETA solutions showed decreased sources of these ERPs in the left inferior temporal gyrus in the tinnitus group. Conclusions: We showed cortico-thalamo-cortical involvements in normoacousic tinnitus with hyperexcitability of the left auditory cortex and inferior temporal gyrus. Significance: This might reflect processes of maladaptive cortical plasticity and memory consolidation. Further validation is needed to establish the value of this tool in customizing therapeutic approach.

More information

Item ID: 41080
DC Identifier: http://oa.upm.es/41080/
OAI Identifier: oai:oa.upm.es:41080
DOI: 10.1016/j.clinph.2015.01.027
Official URL: http://www.sciencedirect.com/science/article/pii/S1388245715000851
Deposited by: Memoria Investigacion
Deposited on: 26 Apr 2017 18:19
Last Modified: 26 Apr 2017 18:19
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