Optical hyperthermia using anti-epidermal growth factor receptor-conjugated gold nanorods to induce cell death in glioblastoma cell lines

Fernández Cabada, Tamara and Sánchez-López de Pablo, Cristina and Pisarchy, Liudmila and Serrano Olmedo, Jose Javier and Ramos Gómez, Milagros (2016). Optical hyperthermia using anti-epidermal growth factor receptor-conjugated gold nanorods to induce cell death in glioblastoma cell lines. "Journal of Nanoscience and Nanotechnology", v. 16 ; pp. 1-7. ISSN 1533-4880. https://doi.org/10.1166/jnn.2016.12570.

Description

Title: Optical hyperthermia using anti-epidermal growth factor receptor-conjugated gold nanorods to induce cell death in glioblastoma cell lines
Author/s:
  • Fernández Cabada, Tamara
  • Sánchez-López de Pablo, Cristina
  • Pisarchy, Liudmila
  • Serrano Olmedo, Jose Javier
  • Ramos Gómez, Milagros
Item Type: Article
Título de Revista/Publicación: Journal of Nanoscience and Nanotechnology
Date: 2016
ISSN: 1533-4880
Volume: 16
Subjects:
Freetext Keywords: Gold Nanorods, EGFR, Optical Hyperthermia, Biofunctionalization, Glioblastoma Cell Lines
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

[img] PDF - Users in campus UPM only - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (342kB)

Abstract

Gold nanorods (GNRs) are able to efficiently convert absorbed light into localized heat within a short period of time due to the surface plasmon resonance effect. This property, along with their easy bioconjugation, allows the use of GNRs in photothermal therapy as selective photothermal agents to target cancer cells. In this study, GNRs were combined with an antibody against anti-epidermal growth factor receptor (EGFR), a receptor that is frequently overexpressed in brain tumors, and the potential of the nanoconjugate (EGFR-GNRs) to eliminate tumor cells was assessed in vitro. Two human glioblastoma cell lines (U373-MG and 1321N1) expressing EGFR at different levels were incubated with unfunctionalized GNRs and EGFR-GNRs, and then exposed to irradiation with a continuous-wave laser at 808 nm. The pretreatment with the EGFR-GNR nanoconjugate significantly increased the cell death rate after laser irradiation compared to unconjugated GNRs. No photothermal cell destruction was observed in the absence of GNRs. Our data suggest that the EGFR modification improves GNR-mediated cell death after laser irradiation, even when EGFR is present at low doses in cancer cells, and may have the potential to be used clinically as a tool to help complete resection of brain tumors during surgery.

Funding Projects

TypeCodeAcronymLeaderTitle
Madrid Regional GovernmentS2010-BMD-2460NEUROTECUnspecifiedUnspecified

More information

Item ID: 41216
DC Identifier: http://oa.upm.es/41216/
OAI Identifier: oai:oa.upm.es:41216
DOI: 10.1166/jnn.2016.12570
Official URL: https://doi.org/10.1166/jnn.2016.12570
Deposited by: Memoria Investigacion
Deposited on: 30 Aug 2016 17:04
Last Modified: 14 Mar 2019 16:40
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM