Structural similarities of human and mammalian lipocalins, and their function in innate immunity and allergy

Jensen Jarolim, Erika; Pacios, Luis F.; Bianchini, G.; Hofstetter, Gerlinde y Roth Walter, Franziska (2016). Structural similarities of human and mammalian lipocalins, and their function in innate immunity and allergy. "Allergy", v. 71 (n. 3); pp. 286-294. ISSN 0105-4538. https://doi.org/10.1111/all.12797.

Descripción

Título: Structural similarities of human and mammalian lipocalins, and their function in innate immunity and allergy
Autor/es:
  • Jensen Jarolim, Erika
  • Pacios, Luis F.
  • Bianchini, G.
  • Hofstetter, Gerlinde
  • Roth Walter, Franziska
Tipo de Documento: Artículo
Título de Revista/Publicación: Allergy
Fecha: Marzo 2016
Volumen: 71
Materias:
Palabras Clave Informales: allergen; animal; canine; iron; lipocalin
Escuela: E.T.S.I. Montes (UPM) [antigua denominación]
Departamento: Sistemas y Recursos Naturales
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Owners and their domestic animals via skin shedding and secretions, mutually exchange microbiomes, potential pathogens and innate immune molecules. Among the latter especially lipocalins are multifaceted: they may have an immunomodulatory function and, furthermore, they represent one of the most important animal allergen families. The amino acid identities, as well as their structures by superposition modeling were compared among human lipocalins, hLCN1 and hLCN2, and most important animal lipocalin allergens, such as Can f 1, Can f 2 and Can f 4 from dog, Fel d 4 from cats, Bos d 5 from cow's milk, Equ c 1 from horses, and Mus m 1 from mice, all of them representing major allergens. The ?-barrel fold with a central molecular pocket is similar among human and animal lipocalins. Thereby, lipocalins are able to transport a variety of biological ligands in their highly conserved calyx-like cavity, among them siderophores with the strongest known capability to complex iron (Fe(3+) ). Levels of human lipocalins are elevated in nonallergic inflammation and cancer, associated with innate immunoregulatory functions that critically depend on ligand load. Accordingly, deficient loading of lipocalin allergens establishes their capacity to induce Th2 hypersensitivity. Our similarity analysis of human and mammalian lipocalins highlights their function in innate immunity and allergy.

Más información

ID de Registro: 41250
Identificador DC: http://oa.upm.es/41250/
Identificador OAI: oai:oa.upm.es:41250
Identificador DOI [BETA]: 10.1111/all.12797
URL Oficial: http://onlinelibrary.wiley.com/doi/10.1111/all.12797/full
Depositado por: Memoria Investigacion
Depositado el: 29 Ago 2016 10:17
Ultima Modificación: 01 Abr 2017 22:30
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