Ultrahigh Sensitivity Slot-Waveguide Biosensor on a Highly Integrated Chip for Simultaneous Diagnosis of Multiple

Hill, Daniel; Sánchez, Benito; Griol Barres, Amadeu; Maire, Guillaume; Dortu, Fabian; Vivien, Laurent; Stragier, Anne-Sophie; Marris-Morini, Delphine; Cassan, Eric; Kazmierczak, Andrzej; Giannone, Domenico; Gylfason, Kristinn B.; Sohlström, Hans; Bañuls, María José; González-Pedro, Victoria; Maquieira, A.; Angulo Barrios, Carlos; Holgado Bolaños, Miguel y Casquel del Campo, Rafael (2008). Ultrahigh Sensitivity Slot-Waveguide Biosensor on a Highly Integrated Chip for Simultaneous Diagnosis of Multiple. En: "Proceedings of Semiconductor Laser Conference, 2008. ISLC 2008. IEEE 21st International", 14/09/2008-18/09/2008, Sorrento, Italia.

Descripción

Título: Ultrahigh Sensitivity Slot-Waveguide Biosensor on a Highly Integrated Chip for Simultaneous Diagnosis of Multiple
Autor/es:
  • Hill, Daniel
  • Sánchez, Benito
  • Griol Barres, Amadeu
  • Maire, Guillaume
  • Dortu, Fabian
  • Vivien, Laurent
  • Stragier, Anne-Sophie
  • Marris-Morini, Delphine
  • Cassan, Eric
  • Kazmierczak, Andrzej
  • Giannone, Domenico
  • Gylfason, Kristinn B.
  • Sohlström, Hans
  • Bañuls, María José
  • González-Pedro, Victoria
  • Maquieira, A.
  • Angulo Barrios, Carlos
  • Holgado Bolaños, Miguel
  • Casquel del Campo, Rafael
Tipo de Documento: Ponencia en Congreso o Jornada (Artículo)
Título del Evento: Proceedings of Semiconductor Laser Conference, 2008. ISLC 2008. IEEE 21st International
Fechas del Evento: 14/09/2008-18/09/2008
Lugar del Evento: Sorrento, Italia
Título del Libro: Proceedings of Semiconductor Laser Conference, 2008. ISLC 2008. IEEE 21st International
Fecha: 2008
Materias:
Escuela: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Departamento: Otro
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

SABIO is a multidisciplinary project involving the emerging fields of micro-nanotechnology, photonics, fluidics and bio-chemistry, targeting a contribution to the development of intelligent diagnostic equipment through the demonstration of a compact polymer based and silicon-based CMOS-compatible micro-nano system. It integrates optical biosensors for label-free biomolecular recognition based on a novel photonic structure named slot-waveguide with immobilized bimolecular receptors on its surface. The slot-waveguides provide high optical intensity in a sub wavelength-size low refractive index region (slot-region) sandwiched between two high refractive index strips (rails) [1] leading to an enhanced interaction between the optical probe and biomolecular complexes (antibody-antigen). As such a biosensor is predicted to exhibit a surface concentration detection-limit lower than 1 pg/mm2, state-of-the-art in label free integrated optical biosensors, as well as the possibility of multiplexed assay, which, together with reduced reaction volumes, leads to the ability to perform rapid multi-analytesensing and comprehensive tests. This offers the further advantageous possibility of assaying several parameters simultaneously and consequently, statistical analysis of these results can potentially increase the reliability and reduce the measurement uncertainty of a diagnostic over single-parameter assays. In addition, the SABIO micro-nano system device applied to its novel protein-based diagnostic technology has the potential to be fast and easy to use, making routine screening or monitoring of diseases more cost-effective.

Más información

ID de Registro: 4142
Identificador DC: http://oa.upm.es/4142/
Identificador OAI: oai:oa.upm.es:4142
URL Oficial: http://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000653
Depositado por: Memoria Investigacion
Depositado el: 17 Sep 2010 11:45
Ultima Modificación: 09 Mar 2016 12:39
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