SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants

Mair, Andrea; Pedrotti, Lorenzo; Wurzinger, Bernhard; Anrather, Dorothea; Simeunovic, Andrea; Weiste, Christoph; Valerio, Concetta; Dietrich, Katrin; Kirchler, Tobias; Naegele, Thomas; Vicente Carbajosa, Jesus; Hanson, Johannes; Baena González, Elena; Chaban, Christina; Weckwerth, Wolfram; Dröege-Laser, Wolfgang y Teige, Markus (2015). SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants. "eLIFE", v. 4 ; pp. 1-33. ISSN 2050-084X. https://doi.org/10.7554/eLife.05828.

Descripción

Título: SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants
Autor/es:
  • Mair, Andrea
  • Pedrotti, Lorenzo
  • Wurzinger, Bernhard
  • Anrather, Dorothea
  • Simeunovic, Andrea
  • Weiste, Christoph
  • Valerio, Concetta
  • Dietrich, Katrin
  • Kirchler, Tobias
  • Naegele, Thomas
  • Vicente Carbajosa, Jesus
  • Hanson, Johannes
  • Baena González, Elena
  • Chaban, Christina
  • Weckwerth, Wolfram
  • Dröege-Laser, Wolfgang
  • Teige, Markus
Tipo de Documento: Artículo
Título de Revista/Publicación: eLIFE
Fecha: 2015
Volumen: 4
Materias:
Escuela: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Departamento: Biotecnología - Biología Vegetal
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Metabolic adjustment to changing environmental conditions, particularly balancing of growth and defense responses, is crucial for all organisms to survive. The evolutionary conserved AMPK/Snf1/SnRK1 kinases are well-known metabolic master regulators in the low-energy response in animals, yeast and plants. They act at two different levels: by modulating the activity of key metabolic enzymes, and by massive transcriptional reprogramming. While the first part is well established, the latter function is only partially understood in animals and not at all in plants. Here we identified the Arabidopsis transcription factor bZIP63 as key regulator of the starvation response and direct target of the SnRK1 kinase. Phosphorylation of bZIP63 by SnRK1 changed its dimerization preference, thereby affecting target gene expression and ultimately primary metabolism. A bzip63 knock-out mutant exhibited starvation-related phenotypes, which could be functionally complemented by wild type bZIP63, but not by a version harboring point mutations in the identified SnRK1 target sites.

Proyectos asociados

TipoCódigoAcrónimoResponsableTítulo
FP7264474MERITUniversiteit Utrecht / University of UtrechtMetabolic Reprogramming by Induction of Transcription

Más información

ID de Registro: 41452
Identificador DC: http://oa.upm.es/41452/
Identificador OAI: oai:oa.upm.es:41452
Identificador DOI: 10.7554/eLife.05828
URL Oficial: https://elifesciences.org/content/4/e05828
Depositado por: Memoria Investigacion
Depositado el: 01 Jul 2016 17:54
Ultima Modificación: 01 Jul 2016 17:54
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