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The major allergens of birch pollen and cow milk, Bet v 1 and Bos d 5, are structurally related to human licocalin 2, enabling them to manipulate T-helper cells depending on their load with siderophore-bound iron
Cita
Jensen Jarolim, Erika; Gomez Casado, Cristina; Fernandez Pacios, Luis; Hofstetter, Gerlinde; Mothes-Luksch, Nadine; Roth, George A.; Singer, J.; Diaz Perales, Araceli y Roth Walter, Franziska (2015). The major allergens of birch pollen and cow milk, Bet v 1 and Bos d 5, are structurally related to human licocalin 2, enabling them to manipulate T-helper cells depending on their load with siderophore-bound iron. En: "2015 AAAAI Annual Meeting", 20/02/2015-24/02/2015, Houston, Texas, USA. p. 1.
Descripción
| Título: | The major allergens of birch pollen and cow milk, Bet v 1 and Bos d 5, are structurally related to human licocalin 2, enabling them to manipulate T-helper cells depending on their load with siderophore-bound iron |
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| Autor/es: |
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| Tipo de Documento: | Ponencia en Congreso o Jornada (Otro) |
| Título del Evento: | 2015 AAAAI Annual Meeting |
| Fechas del Evento: | 20/02/2015-24/02/2015 |
| Lugar del Evento: | Houston, Texas, USA |
| Título del Libro: | Journal of Allergy and Clinical Immunology |
| Fecha: | 2015 |
| Volumen: | 135 |
| Materias: | |
| Escuela: | E.T.S.I. Agrónomos (UPM) [antigua denominación] |
| Departamento: | Biotecnología - Biología Vegetal |
| Licencias Creative Commons: | Reconocimiento - Sin obra derivada - No comercial |
Resumen
We conclude that Bet v 1 and Bos d 5 not only structurally mimic human LCN2, but also functionally by their ability to bind iron via siderophores. The apo-forms promote Th2 cells, whereas the holo-forms appear to be immunosuppressive. These results provide for the first time a functional understanding on the principle of allergenicity of major allergens from entirely independent sources, like birch and milk.
Más información
| ID de Registro: | 41577 |
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| Identificador DC: | http://oa.upm.es/41577/ |
| Identificador OAI: | oai:oa.upm.es:41577 |
| URL Oficial: | https://aaaai.confex.com/aaaai/2015/webprogram/meeting.html |
| Depositado por: | Memoria Investigacion |
| Depositado el: | 29 Jun 2016 14:17 |
| Ultima Modificación: | 29 Jun 2016 14:17 |
