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The major allergens of birch pollen and cow milk, Bet v 1 and Bos d 5, are structurally related to human licocalin 2, enabling them to manipulate T-helper cells depending on their load with siderophore-bound iron
Citation
Jensen Jarolim, Erika and Gomez Casado, Cristina and Fernandez Pacios, Luis and Hofstetter, Gerlinde and Mothes-Luksch, Nadine and Roth, George A. and Singer, J. and Diaz Perales, Araceli and Roth Walter, Franziska (2015). The major allergens of birch pollen and cow milk, Bet v 1 and Bos d 5, are structurally related to human licocalin 2, enabling them to manipulate T-helper cells depending on their load with siderophore-bound iron. In: "2015 AAAAI Annual Meeting", 20/02/2015-24/02/2015, Houston, Texas, USA. p. 1.
Description
| Title: | The major allergens of birch pollen and cow milk, Bet v 1 and Bos d 5, are structurally related to human licocalin 2, enabling them to manipulate T-helper cells depending on their load with siderophore-bound iron |
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| Author/s: |
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| Item Type: | Presentation at Congress or Conference (Other) |
| Event Title: | 2015 AAAAI Annual Meeting |
| Event Dates: | 20/02/2015-24/02/2015 |
| Event Location: | Houston, Texas, USA |
| Title of Book: | Journal of Allergy and Clinical Immunology |
| Date: | 2015 |
| Volume: | 135 |
| Subjects: | |
| Faculty: | E.T.S.I. Agrónomos (UPM) [antigua denominación] |
| Department: | Biotecnología - Biología Vegetal |
| Creative Commons Licenses: | Recognition - No derivative works - Non commercial |
Abstract
We conclude that Bet v 1 and Bos d 5 not only structurally mimic human LCN2, but also functionally by their ability to bind iron via siderophores. The apo-forms promote Th2 cells, whereas the holo-forms appear to be immunosuppressive. These results provide for the first time a functional understanding on the principle of allergenicity of major allergens from entirely independent sources, like birch and milk.
More information
| Item ID: | 41577 |
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| DC Identifier: | http://oa.upm.es/41577/ |
| OAI Identifier: | oai:oa.upm.es:41577 |
| Official URL: | https://aaaai.confex.com/aaaai/2015/webprogram/meeting.html |
| Deposited by: | Memoria Investigacion |
| Deposited on: | 29 Jun 2016 14:17 |
| Last Modified: | 29 Jun 2016 14:17 |
