The major allergens of birch pollen and cow milk, Bet v 1 and Bos d 5, are structurally related to human licocalin 2, enabling them to manipulate T-helper cells depending on their load with siderophore-bound iron

Jensen Jarolim, Erika and Gomez Casado, Cristina and Fernandez Pacios, Luis and Hofstetter, Gerlinde and Mothes-Luksch, Nadine and Roth, George A. and Singer, J. and Diaz Perales, Araceli and Roth Walter, Franziska (2015). The major allergens of birch pollen and cow milk, Bet v 1 and Bos d 5, are structurally related to human licocalin 2, enabling them to manipulate T-helper cells depending on their load with siderophore-bound iron. In: "2015 AAAAI Annual Meeting", 20/02/2015-24/02/2015, Houston, Texas, USA. p. 1.

Description

Title: The major allergens of birch pollen and cow milk, Bet v 1 and Bos d 5, are structurally related to human licocalin 2, enabling them to manipulate T-helper cells depending on their load with siderophore-bound iron
Author/s:
  • Jensen Jarolim, Erika
  • Gomez Casado, Cristina
  • Fernandez Pacios, Luis
  • Hofstetter, Gerlinde
  • Mothes-Luksch, Nadine
  • Roth, George A.
  • Singer, J.
  • Diaz Perales, Araceli
  • Roth Walter, Franziska
Item Type: Presentation at Congress or Conference (Other)
Event Title: 2015 AAAAI Annual Meeting
Event Dates: 20/02/2015-24/02/2015
Event Location: Houston, Texas, USA
Title of Book: Journal of Allergy and Clinical Immunology
Date: 2015
Volume: 135
Subjects:
Faculty: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Department: Biotecnología - Biología Vegetal
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

We conclude that Bet v 1 and Bos d 5 not only structurally mimic human LCN2, but also functionally by their ability to bind iron via siderophores. The apo-forms promote Th2 cells, whereas the holo-forms appear to be immunosuppressive. These results provide for the first time a functional understanding on the principle of allergenicity of major allergens from entirely independent sources, like birch and milk.

More information

Item ID: 41577
DC Identifier: http://oa.upm.es/41577/
OAI Identifier: oai:oa.upm.es:41577
Official URL: https://aaaai.confex.com/aaaai/2015/webprogram/meeting.html
Deposited by: Memoria Investigacion
Deposited on: 29 Jun 2016 14:17
Last Modified: 29 Jun 2016 14:17
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