Altered functional connectivity in essential tremor

Benito León, Julián and Louis, Elan D. and Romero Muñoz, Juan Pablo and Hernández Tamames, J.A. and Manzanedo Sáenz, Eva and Álvarez Linera, Juan and Bermejo Pareja, Félix and Posada Rodríguez, Ignacio Javier and Rocón de Lima, Eduardo (2015). Altered functional connectivity in essential tremor. "Medicine", v. 94 (n. 49); pp. 1-9. ISSN 0025-7974. https://doi.org/10.1097/MD.0000000000001936.

Description

Title: Altered functional connectivity in essential tremor
Author/s:
  • Benito León, Julián
  • Louis, Elan D.
  • Romero Muñoz, Juan Pablo
  • Hernández Tamames, J.A.
  • Manzanedo Sáenz, Eva
  • Álvarez Linera, Juan
  • Bermejo Pareja, Félix
  • Posada Rodríguez, Ignacio Javier
  • Rocón de Lima, Eduardo
Item Type: Article
Título de Revista/Publicación: Medicine
Date: December 2015
ISSN: 0025-7974
Volume: 94
Subjects:
Faculty: Centro de Automática y Robótica (CAR) UPM-CSIC
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Essential tremor (ET) has been associated with a spectrum of clinical features, with both motor and nonmotor elements, including cognitive deficits. We employed resting-state functional magnetic resonance imaging (fMRI) to assess whether brain networks that might be involved in the pathogenesis of nonmotor manifestations associated with ET are altered, and the relationship between abnormal connectivity and ET severity and neuropsychological function. Resting-state fMRI data in 23 ET patients (12 women and 11 men) and 22 healthy controls (HC) (12 women and 10 men) were analyzed using independent component analysis, in combination with a ‘‘dualregression’’ technique, to identify the group differences of resting-state networks (RSNs) (default mode network [DMN] and executive, frontoparietal, sensorimotor, cerebellar, auditory/language, and visual networks). All participants underwent a neuropsychological and neuroimaging session, where resting-state data were collected. Relative to HC, ET patients showed increased connectivity in RSNs involved in cognitive processes (DMN and frontoparietal networks) and decreased connectivity in the cerebellum and visual networks. Changes in network integrity were associated not only with ET severity (DMN) and ET duration (DMN and left frontoparietal network), but also with cognitive ability.Moreover, in at least 3 networks (DMN and frontoparietal networks), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, verbal memory, visual memory, and language) and depressive symptoms. Further, in the visual network, decreased connectivity was associated with worse performance on visuospatial ability. ET was associated with abnormal brain connectivity in major RSNs that might be involved in both motor and nonmotor symptoms.

More information

Item ID: 43639
DC Identifier: http://oa.upm.es/43639/
OAI Identifier: oai:oa.upm.es:43639
DOI: 10.1097/MD.0000000000001936
Official URL: https://insights.ovid.com/crossref?an=00005792-201512080-00005
Deposited by: Memoria Investigacion
Deposited on: 02 Apr 2017 08:45
Last Modified: 10 Jun 2019 12:47
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