Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor

Gallego Juárez, Juan Antonio and Dideriksen, Jacob L. and Holobar, Ales and Ibañez Pereda, Jaime and Pons Rovira, José Luis and Louis, Elan D. and Rocón de Lima, Eduardo and Farina, Darío (2014). Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor. "Journal of neurophysiology" (n. 113); pp. 182-191. ISSN 0022-3077. https://doi.org/10.1152/jn.00531.2014.

Description

Title: Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor
Author/s:
  • Gallego Juárez, Juan Antonio
  • Dideriksen, Jacob L.
  • Holobar, Ales
  • Ibañez Pereda, Jaime
  • Pons Rovira, José Luis
  • Louis, Elan D.
  • Rocón de Lima, Eduardo
  • Farina, Darío
Item Type: Article
Título de Revista/Publicación: Journal of neurophysiology
Date: 1 October 2014
ISSN: 0022-3077
Subjects:
Freetext Keywords: pathological tremor; motor unit; motor neuron; coherence; EMG;EEG
Faculty: Centro de Automática y Robótica (CAR) UPM-CSIC
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Tremor in essential tremor (ET) is generated by pathological oscillations at 4 to 12 Hz, likely originating at cerebello-thalamo-cortical pathways. However, the way in which tremor is represented in the output of the spinal cord circuitries is largely unknown because of the difficulties in identifying the behavior of individual motor units from tremulous muscles. By using novel methods for the decomposition of multichannel surface EMG, we provide a systematic analysis of the discharge properties of motor units in 9 ET patients, with concurrent recordings of EEG activity. This analysis allowed inferring the contribution of common synaptic inputs to motor neurons in ET. Motor unit short-term synchronization was significantly greater in ET patients than in healthy subjects. Further, the strong association between the degree of synchronization and the peak in coherence between motor unit spike trains at the tremor frequency indicated that the high synchronization levels were generated mainly by common synaptic inputs specifically at the tremor frequency. The coherence between EEG and motor unit spike trains demonstrated the presence of common cortical input to the motor neurons at the tremor frequency. Nonetheless, the strength of this input was uncorrelated to the net common synaptic input at the tremor frequency, suggesting a contribution of spinal afferents or secondary supraspinal pathways in projecting common input at the tremor frequency. These results provide the first systematic analysis of the neural drive to the muscle in ET and elucidate some of its characteristics that determine the pathological tremulous muscle activity

Funding Projects

TypeCodeAcronymLeaderTitle
FP7EU-FP7-2011-287739NeuroTREMORUnspecifiedUnspecified

More information

Item ID: 43643
DC Identifier: http://oa.upm.es/43643/
OAI Identifier: oai:oa.upm.es:43643
DOI: 10.1152/jn.00531.2014
Official URL: http://jn.physiology.org/content/early/2014/09/24/jn.00531.2014
Deposited by: Memoria Investigacion
Deposited on: 03 Apr 2017 17:43
Last Modified: 13 Jun 2019 07:31
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