Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor

Gallego Juárez, Juan Antonio; Dideriksen, Jacob L.; Holobar, Ales; Ibañez Pereda, Jaime; Pons Rovira, José Luis; Louis, Elan D.; Rocón de Lima, Eduardo y Farina, Darío (2014). Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor. "Journal of neurophysiology" (n. 113); pp. 182-191. ISSN 0022-3077. https://doi.org/10.1152/jn.00531.2014..

Descripción

Título: Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor
Autor/es:
  • Gallego Juárez, Juan Antonio
  • Dideriksen, Jacob L.
  • Holobar, Ales
  • Ibañez Pereda, Jaime
  • Pons Rovira, José Luis
  • Louis, Elan D.
  • Rocón de Lima, Eduardo
  • Farina, Darío
Tipo de Documento: Artículo
Título de Revista/Publicación: Journal of neurophysiology
Fecha: 1 Octubre 2014
Materias:
Palabras Clave Informales: pathological tremor; motor unit; motor neuron; coherence; EMG;EEG
Escuela: Centro de Automática y Robótica (CAR) UPM-CSIC
Departamento: Otro
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Tremor in essential tremor (ET) is generated by pathological oscillations at 4 to 12 Hz, likely originating at cerebello-thalamo-cortical pathways. However, the way in which tremor is represented in the output of the spinal cord circuitries is largely unknown because of the difficulties in identifying the behavior of individual motor units from tremulous muscles. By using novel methods for the decomposition of multichannel surface EMG, we provide a systematic analysis of the discharge properties of motor units in 9 ET patients, with concurrent recordings of EEG activity. This analysis allowed inferring the contribution of common synaptic inputs to motor neurons in ET. Motor unit short-term synchronization was significantly greater in ET patients than in healthy subjects. Further, the strong association between the degree of synchronization and the peak in coherence between motor unit spike trains at the tremor frequency indicated that the high synchronization levels were generated mainly by common synaptic inputs specifically at the tremor frequency. The coherence between EEG and motor unit spike trains demonstrated the presence of common cortical input to the motor neurons at the tremor frequency. Nonetheless, the strength of this input was uncorrelated to the net common synaptic input at the tremor frequency, suggesting a contribution of spinal afferents or secondary supraspinal pathways in projecting common input at the tremor frequency. These results provide the first systematic analysis of the neural drive to the muscle in ET and elucidate some of its characteristics that determine the pathological tremulous muscle activity

Proyectos asociados

TipoCódigoAcrónimoResponsableTítulo
FP7EU-FP7-2011-287739NeuroTREMORSin especificarSin especificar

Más información

ID de Registro: 43643
Identificador DC: http://oa.upm.es/43643/
Identificador OAI: oai:oa.upm.es:43643
Identificador DOI: 10.1152/jn.00531.2014.
URL Oficial: http://jn.physiology.org/content/early/2014/09/24/jn.00531.2014
Depositado por: Memoria Investigacion
Depositado el: 03 Abr 2017 17:43
Ultima Modificación: 03 Abr 2017 17:43
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