Dendritic and axonal wiring optimization of cortical GABAergic interneurons

Antón Sánchez, Laura and Bielza Lozoya, María Concepción and Benavides Piccione, Ruth and Felipe Oroquieta, Javier de and Larrañaga Múgica, Pedro (2016). Dendritic and axonal wiring optimization of cortical GABAergic interneurons. "Neuroinformatics", v. 14 (n. 4); pp. 453-464. ISSN 1539-2791. https://doi.org/10.1007/s12021-016-9309-6.

Description

Title: Dendritic and axonal wiring optimization of cortical GABAergic interneurons
Author/s:
  • Antón Sánchez, Laura
  • Bielza Lozoya, María Concepción
  • Benavides Piccione, Ruth
  • Felipe Oroquieta, Javier de
  • Larrañaga Múgica, Pedro
Item Type: Article
Título de Revista/Publicación: Neuroinformatics
Date: 2016
Volume: 14
Subjects:
Freetext Keywords: Neocortex; Wiring economy; Interneurons; Dendritic and axonal arborizations; Graph theory; Evolutionary computation
Faculty: E.T.S. de Ingenieros Informáticos (UPM)
Department: Inteligencia Artificial
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The way in which a neuronal tree expands plays an important role in its functional and computational characteristics. We aimed to study the existence of an optimal neuronal design for different types of cortical GABAergic neurons. To do this, we hypothesized that both the axonal and dendritic trees of individual neurons optimize brain connectivity in terms of wiring length. We took the branching points of real three-dimensional neuronal reconstructions of the axonal and dendritic trees of different types of cortical interneurons and searched for the minimal wiring arborization structure that respects the branching points. We compared the minimal wiring arborization with real axonal and dendritic trees. We tested this optimization problem using a new approach based on graph theory and evolutionary computation techniques. We concluded that neuronal wiring is near-optimal in most of the tested neurons, although the wiring length of dendritic trees is generally nearer to the optimum. Therefore, wiring economy is related to the way in which neuronal arborizations grow irrespective of the marked differences in the morphology of the examined interneurons.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainC080020-09UnspecifiedEPFLBlue Brain Porject
Madrid Regional GovernmentTIN2013-41592-PS2013/ICE-2845-CASI-CAM-CM projectUniversidad Politécnica de MadridUnspecified
FP7604102HBPUnspecifiedThe Human Brain Project

More information

Item ID: 45495
DC Identifier: http://oa.upm.es/45495/
OAI Identifier: oai:oa.upm.es:45495
DOI: 10.1007/s12021-016-9309-6
Official URL: https://link.springer.com/article/10.1007/s12021-016-9309-6
Deposited by: Memoria Investigacion
Deposited on: 19 Jul 2017 08:29
Last Modified: 19 Mar 2019 14:26
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