Wiring economy of pyramidal cells in the juvenile rat somatosensory cortex

Antón Sánchez, Laura and Bielza Lozoya, María Concepción and Larrañaga Múgica, Pedro María and Felipe Oroquieta, Javier de (2016). Wiring economy of pyramidal cells in the juvenile rat somatosensory cortex. "Plos One", v. 11 ; pp. 1-10. ISSN 1932-6203. https://doi.org/10.1371/journal.pone.0165915.

Description

Title: Wiring economy of pyramidal cells in the juvenile rat somatosensory cortex
Author/s:
  • Antón Sánchez, Laura
  • Bielza Lozoya, María Concepción
  • Larrañaga Múgica, Pedro María
  • Felipe Oroquieta, Javier de
Item Type: Article
Título de Revista/Publicación: Plos One
Date: November 2016
ISSN: 1932-6203
Volume: 11
Subjects:
Faculty: E.T.S. de Ingenieros Informáticos (UPM)
Department: Inteligencia Artificial
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Ever since Cajal hypothesized that the structure of neurons is designed in such a way as to save space, time and matter, numerous researchers have analyzed wiring properties at different scales of brain organization. Here we test the hypothesis that individual pyramidal cells, the most abundant type of neuron in the cerebral cortex, optimize brain connectivity in terms of wiring length. In this study, we analyze the neuronal wiring of complete basal arborizations of pyramidal neurons in layer II, III, IV, Va, Vb and VI of the hindlimb somatosensory cortical region of postnatal day 14 rats. For each cell, we search for the optimal basal arborization and compare its length with the length of the real dendritic structure. Here the optimal arborization is defined as the arborization that has the shortest total wiring length provided that all neuron bifurcations are respected and the extent of the dendritic arborizations remain unchanged. We use graph theory and evolutionary computation techniques to search for the minimal wiring arborizations. Despite morphological differences between pyramidal neurons located in different cortical layers, we found that the neuronal wiring is near-optimal in all cases (the biggest difference between the shortest synthetic wiring found for a dendritic arborization and the length of its real wiring was less than 5%). We found, however, that the real neuronal wiring was significantly closer to the best solution found in layers II, III and IV. Our studies show that the wiring economy of cortical neurons is related not to the type of neurons or their morphological complexities but to general wiring economy principles.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainC080020-09UnspecifiedUnspecifiedCajal Blue Brain
Government of SpainTIN2013-41592-PUnspecifiedUnspecifiedAprendizaje de redes bayesianas con variables sin y con direccionalidad para descubrimiento de asociaciones, predicción multirespuesta y clustering
Madrid Regional GovernmentS2013/ICE-2845-CASI-CAM-CMUnspecifiedUnspecifiedUnspecified
Horizon 2020720270UnspecifiedUnspecifiedUnspecified

More information

Item ID: 45501
DC Identifier: http://oa.upm.es/45501/
OAI Identifier: oai:oa.upm.es:45501
DOI: 10.1371/journal.pone.0165915
Official URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165915
Deposited by: Memoria Investigacion
Deposited on: 06 Oct 2017 09:59
Last Modified: 19 Mar 2019 14:39
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