The effects of sildenafil citrate on the fetoplacental development and hemodynamics in a rabbit model of intrauterina growth restriction

López Tello, J.; Arias Álvarez, M.; Jiménez Martínez, María Ángeles; Barbero Fernández, Alicia; García García, R. M.; Rodríguez, María; Lorenzo, P.L.; Torres Rovira, Laura; Astiz, S.; González Bulnes, Antonio y García Rebollar, Pilar (2017). The effects of sildenafil citrate on the fetoplacental development and hemodynamics in a rabbit model of intrauterina growth restriction. "Reproduction, Fertility, And Development", v. 29 (n. 6); pp. 1239-1248. ISSN 1031-3613. https://doi.org/10.1071/RD15330.

Descripción

Título: The effects of sildenafil citrate on the fetoplacental development and hemodynamics in a rabbit model of intrauterina growth restriction
Autor/es:
  • López Tello, J.
  • Arias Álvarez, M.
  • Jiménez Martínez, María Ángeles
  • Barbero Fernández, Alicia
  • García García, R. M.
  • Rodríguez, María
  • Lorenzo, P.L.
  • Torres Rovira, Laura
  • Astiz, S.
  • González Bulnes, Antonio
  • García Rebollar, Pilar
Tipo de Documento: Artículo
Título de Revista/Publicación: Reproduction, Fertility, And Development
Fecha: Mayo 2017
Volumen: 29
Materias:
Escuela: E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Departamento: Producción Agraria
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

The present study evaluated the effectiveness of sildenafil citrate (SC) to improve placental and fetal growth in a diet-induced rabbit model of intrauterine growth restriction (IUGR). Pregnant rabbits were fed either ad libitum (Group C) or restricted to 50% of dietary requirements (Group R) or restricted and treated with SC (Group SC). The treatment with SC improved placental development by increasing vascularity and vessel hypertrophy in the decidua. The assessment of feto–placental haemodynamics showed higher resistance and pulsatility indices at the middle cerebral artery (MCA) in fetuses treated with SC when compared with Group R, which had increased systolic peak and time-averaged mean velocities at the MCA. Furthermore, fetuses in the SC group had significantly higher biparietal and thoracic diameters and longer crown–rump lengths than fetuses in Group R. Hence, the SC group had a reduced IUGR rate and a higher kit size at birth compared with Group R. In conclusion, SC may provide potential benefits in pregnancies with placental insufficiency and IUGR, partially counteracting the negative effects of food restriction on placental development and fetal growth. However, the present study also found evidence of a possible blood overflow in the brain that warrants further investigation.

Más información

ID de Registro: 45757
Identificador DC: http://oa.upm.es/45757/
Identificador OAI: oai:oa.upm.es:45757
Identificador DOI: 10.1071/RD15330
URL Oficial: http://www.publish.csiro.au/RD/RD15330
Depositado por: Memoria Investigacion
Depositado el: 22 May 2017 15:45
Ultima Modificación: 22 May 2017 15:45
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