The effects of sildenafil citrate on the fetoplacental development and hemodynamics in a rabbit model of intrauterina growth restriction

López Tello, J. and Arias Álvarez, M. and Jiménez Martínez, María Ángeles and Barbero Fernández, Alicia and García García, R. M. and Rodríguez, María and Lorenzo, P.L. and Torres Rovira, Laura and Astiz, S. and González Bulnes, Antonio and García Rebollar, Pilar (2017). The effects of sildenafil citrate on the fetoplacental development and hemodynamics in a rabbit model of intrauterina growth restriction. "Reproduction, Fertility, And Development", v. 29 (n. 6); pp. 1239-1248. ISSN 1031-3613. https://doi.org/10.1071/RD15330.

Description

Title: The effects of sildenafil citrate on the fetoplacental development and hemodynamics in a rabbit model of intrauterina growth restriction
Author/s:
  • López Tello, J.
  • Arias Álvarez, M.
  • Jiménez Martínez, María Ángeles
  • Barbero Fernández, Alicia
  • García García, R. M.
  • Rodríguez, María
  • Lorenzo, P.L.
  • Torres Rovira, Laura
  • Astiz, S.
  • González Bulnes, Antonio
  • García Rebollar, Pilar
Item Type: Article
Título de Revista/Publicación: Reproduction, Fertility, And Development
Date: May 2017
Volume: 29
Subjects:
Faculty: E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Department: Producción Agraria
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The present study evaluated the effectiveness of sildenafil citrate (SC) to improve placental and fetal growth in a diet-induced rabbit model of intrauterine growth restriction (IUGR). Pregnant rabbits were fed either ad libitum (Group C) or restricted to 50% of dietary requirements (Group R) or restricted and treated with SC (Group SC). The treatment with SC improved placental development by increasing vascularity and vessel hypertrophy in the decidua. The assessment of feto–placental haemodynamics showed higher resistance and pulsatility indices at the middle cerebral artery (MCA) in fetuses treated with SC when compared with Group R, which had increased systolic peak and time-averaged mean velocities at the MCA. Furthermore, fetuses in the SC group had significantly higher biparietal and thoracic diameters and longer crown–rump lengths than fetuses in Group R. Hence, the SC group had a reduced IUGR rate and a higher kit size at birth compared with Group R. In conclusion, SC may provide potential benefits in pregnancies with placental insufficiency and IUGR, partially counteracting the negative effects of food restriction on placental development and fetal growth. However, the present study also found evidence of a possible blood overflow in the brain that warrants further investigation.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainAGL2011–23822UnspecifiedUnspecifiedUnspecified
Madrid Regional GovernmentS2013/ABI-2913UnspecifiedUnspecifiedUnspecified

More information

Item ID: 45757
DC Identifier: http://oa.upm.es/45757/
OAI Identifier: oai:oa.upm.es:45757
DOI: 10.1071/RD15330
Official URL: http://www.publish.csiro.au/RD/RD15330
Deposited by: Memoria Investigacion
Deposited on: 22 May 2017 15:45
Last Modified: 13 Mar 2019 11:49
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