Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention

Szendrei Szabo, Barbara and Gonzalez-Lamuno, Domingo and Amigo, Teresa and Wang, Guan and Pitsiladis, Yannis and Benito Peinado, Pedro José and Gomez-Candela, Carmen and Calderon Montero, Francisco Javier and Cupeiro Coto, Rocío (2016). Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention. "Applied Physiology Nutrition and Metabolism", v. 41 (n. 3); pp. 307-314. ISSN 1715-5312. https://doi.org/10.1139/apnm-2015-0425.

Description

Title: Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention
Author/s:
  • Szendrei Szabo, Barbara
  • Gonzalez-Lamuno, Domingo
  • Amigo, Teresa
  • Wang, Guan
  • Pitsiladis, Yannis
  • Benito Peinado, Pedro José
  • Gomez-Candela, Carmen
  • Calderon Montero, Francisco Javier
  • Cupeiro Coto, Rocío
Item Type: Article
Título de Revista/Publicación: Applied Physiology Nutrition and Metabolism
Date: 2016
ISSN: 1715-5312
Volume: 41
Subjects:
Freetext Keywords: β-adrenergic receptors, weight loss, body composition, Gln27Glu and Trp64Arg, exercise and diet
Faculty: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Department: Salud y Rendimiento Humano
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The β-2 and β-3 adrenergic receptors (ADRB2 and ADRB3) are thought to play a role in energy expenditure and lipolysis. However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial. The aim of this study was to investigate the effect of these polymorphisms on changes in weight and body composition during a controlled weight-loss program. One hundred seventy-three healthy overweight and obese participants (91 women, 82 men) aged 18–50 years participated in a 22-week-long intervention based on a hypocaloric diet and exercise. They were randomly assigned to 1 of 4 groups: strength, endurance, strength and endurance combined, and physical activity recommendations only. Body weight, body mass index (BMI), and body composition variables were assessed before and after the intervention. Genetic analysis was carried out according to standard protocols. No effect of the ADRB2 gene was shown on final weight, BMI, or body composition, although in the supervised male group, Glu27 carriers tended to have greater weight (p = 0.019, 2.5 kg) and BMI (p = 0.019, 0.88 kg/m2) reductions than did noncarriers. There seems to be an individual effect of the ADRB3 polymorphism on fat mass (p = 0.004) and fat percentage (p = 0.036), in addition to an interaction with exercise for fat mass (p = 0.038). After the intervention, carriers of the Arg64 allele had a greater fat mass and fat percentage than did noncarriers (p = 0.004, 2.8 kg). In conclusion, the ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition, although the current evidence is weak; however, further studies are necessary to clarify their roles.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainDEP2008-06354-C04-01PRONAFUnspecifiedPROgramas de Nutrición y Actividad Física para el tratamiento de la obesidad

More information

Item ID: 45788
DC Identifier: http://oa.upm.es/45788/
OAI Identifier: oai:oa.upm.es:45788
DOI: 10.1139/apnm-2015-0425
Official URL: http://www.nrcresearchpress.com/doi/10.1139/apnm-2015-0425#.WVtF5rhLdkg
Deposited by: Memoria Investigacion
Deposited on: 04 Jul 2017 07:45
Last Modified: 19 Mar 2019 16:33
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