Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention

Szendrei Szabo, Barbara; Gonzalez-Lamuno, Domingo; Amigo, Teresa; Wang, Guan; Pitsiladis, Yannis; Benito Peinado, Pedro José; Gomez-Candela, Carmen; Calderon Montero, Francisco Javier y Cupeiro Coto, Rocío (2016). Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention. "Applied Physiology Nutrition and Metabolism", v. 41 (n. 3); pp. 307-314. ISSN 1715-5312. https://doi.org/10.1139/apnm-2015-0425.

Descripción

Título: Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention
Autor/es:
  • Szendrei Szabo, Barbara
  • Gonzalez-Lamuno, Domingo
  • Amigo, Teresa
  • Wang, Guan
  • Pitsiladis, Yannis
  • Benito Peinado, Pedro José
  • Gomez-Candela, Carmen
  • Calderon Montero, Francisco Javier
  • Cupeiro Coto, Rocío
Tipo de Documento: Artículo
Título de Revista/Publicación: Applied Physiology Nutrition and Metabolism
Fecha: 2016
Volumen: 41
Materias:
Palabras Clave Informales: β-adrenergic receptors, weight loss, body composition, Gln27Glu and Trp64Arg, exercise and diet
Escuela: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Departamento: Salud y Rendimiento Humano
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

The β-2 and β-3 adrenergic receptors (ADRB2 and ADRB3) are thought to play a role in energy expenditure and lipolysis. However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial. The aim of this study was to investigate the effect of these polymorphisms on changes in weight and body composition during a controlled weight-loss program. One hundred seventy-three healthy overweight and obese participants (91 women, 82 men) aged 18–50 years participated in a 22-week-long intervention based on a hypocaloric diet and exercise. They were randomly assigned to 1 of 4 groups: strength, endurance, strength and endurance combined, and physical activity recommendations only. Body weight, body mass index (BMI), and body composition variables were assessed before and after the intervention. Genetic analysis was carried out according to standard protocols. No effect of the ADRB2 gene was shown on final weight, BMI, or body composition, although in the supervised male group, Glu27 carriers tended to have greater weight (p = 0.019, 2.5 kg) and BMI (p = 0.019, 0.88 kg/m2) reductions than did noncarriers. There seems to be an individual effect of the ADRB3 polymorphism on fat mass (p = 0.004) and fat percentage (p = 0.036), in addition to an interaction with exercise for fat mass (p = 0.038). After the intervention, carriers of the Arg64 allele had a greater fat mass and fat percentage than did noncarriers (p = 0.004, 2.8 kg). In conclusion, the ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition, although the current evidence is weak; however, further studies are necessary to clarify their roles.

Más información

ID de Registro: 45788
Identificador DC: http://oa.upm.es/45788/
Identificador OAI: oai:oa.upm.es:45788
Identificador DOI: 10.1139/apnm-2015-0425
URL Oficial: http://www.nrcresearchpress.com/doi/10.1139/apnm-2015-0425#.WVtF5rhLdkg
Depositado por: Memoria Investigacion
Depositado el: 04 Jul 2017 07:45
Ultima Modificación: 04 Jul 2017 07:45
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