Androgen receptor gene polymorphism influence fat accumulation: a longitudinal study from adolescence to adult age.

Ponce González, J. G. and Rodríguez García, L. and Losa Reyna, J. and Guadalupe Grau, Amelia and Rodríguez González, F. G. and Díaz Chico, B. N. and Dorado, Cecilia and Serrano Sánchez, José Antonio and Calbet, J. A. L. (2016). Androgen receptor gene polymorphism influence fat accumulation: a longitudinal study from adolescence to adult age.. "Scandinavian Journal of Medicine & Science in Sports", v. 26 (n. 11); pp. 1313-1320. ISSN 0905-7188. https://doi.org/10.1111/sms.12587.

Description

Title: Androgen receptor gene polymorphism influence fat accumulation: a longitudinal study from adolescence to adult age.
Author/s:
  • Ponce González, J. G.
  • Rodríguez García, L.
  • Losa Reyna, J.
  • Guadalupe Grau, Amelia
  • Rodríguez González, F. G.
  • Díaz Chico, B. N.
  • Dorado, Cecilia
  • Serrano Sánchez, José Antonio
  • Calbet, J. A. L.
Item Type: Article
Título de Revista/Publicación: Scandinavian Journal of Medicine & Science in Sports
Date: November 2016
ISSN: 0905-7188
Volume: 26
Subjects:
Faculty: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Department: Salud y Rendimiento Humano
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

To determine the influence of androgen receptor CAG and GGN repeat polymorphisms on fat mass and maximal fat oxidation (MFO), CAG and GGN repeat lengths were measured in 128 young boys, from which longitudinal data were obtained in 45 of them [mean?±?SD: 12.8?±?3.6 years old at recruitment, and 27.0?±?4.8 years old at adult age]. Subjects were grouped as CAG short (CAGS ) if harboring repeat lengths ?21, the rest as CAG long (CAGL ); and GGN short (GGNS ) if GGN repeat lengths ?23, or long if >?23 (GGNL ). CAGS and GGNS were associated with lower adiposity than CAGL or GGNL (P?<?0.05). There was an association between the logarithm of CAG repeats polymorphism and the changes of body mass (r?=?0.34, P?=?0.03). At adult age, CAGS men showed lower accumulation of total body and trunk fat mass, and lower resting metabolic rate (RMR) and MFO per kg of total lean mass compared with CAGL (P?<?0.05). GGNS men also showed lower percentage of body fat (P?<?0.05). In summary, androgen receptor CAG and GGN repeat polymorphisms are associated with RMR, MFO, fat mass, and its regional distribution in healthy male adolescents, influencing fat accumulation from adolescence to adult age.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainDEP2006-56076-C06-04/ACTIUnspecifiedUnspecifiedUnspecified

More information

Item ID: 46233
DC Identifier: http://oa.upm.es/46233/
OAI Identifier: oai:oa.upm.es:46233
DOI: 10.1111/sms.12587
Official URL: https://onlinelibrary.wiley.com/doi/full/10.1111/sms.12587
Deposited by: Memoria Investigacion
Deposited on: 06 Jul 2017 09:30
Last Modified: 04 Jun 2019 08:51
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