A clinical method for mapping and quantifying blood stasis in the left ventricle

Rossini, Lorenzo and Martínez Legazpi, Pablo and Vu, Vi and Fernández Friera, Leticia and Pérez del Villar Moro, Candelas and Rodríguez López, Sara and Benito Mate, Yolanda and Borja, María Guadalupe and Pastor Escuredo, David and Yotti, Raquel and Ledesma Carbayo, Maria Jesus and Kahn, Andrew M. and Ibañez, Borja and Fernández Avilés, Francisco and Newman, Karen May and Bermejo Parra, Javier and Álamo de Pedro, Juan Carlos del (2016). A clinical method for mapping and quantifying blood stasis in the left ventricle. "Journal of biomechanics", v. 49 (n. 11); pp. 2152-2161. ISSN 0021-9290. https://doi.org/10.1016/j.jbiomech.2015.11.049.


Title: A clinical method for mapping and quantifying blood stasis in the left ventricle
  • Rossini, Lorenzo
  • Martínez Legazpi, Pablo
  • Vu, Vi
  • Fernández Friera, Leticia
  • Pérez del Villar Moro, Candelas
  • Rodríguez López, Sara
  • Benito Mate, Yolanda
  • Borja, María Guadalupe
  • Pastor Escuredo, David
  • Yotti, Raquel
  • Ledesma Carbayo, Maria Jesus
  • Kahn, Andrew M.
  • Ibañez, Borja
  • Fernández Avilés, Francisco
  • Newman, Karen May
  • Bermejo Parra, Javier
  • Álamo de Pedro, Juan Carlos del
Item Type: Article
Título de Revista/Publicación: Journal of biomechanics
Date: 7 November 2016
ISSN: 0021-9290
Volume: 49
Freetext Keywords: Blood stasis; Residence time; Intraventricular thrombosis; Left ventricular assist devices; Echocardiography; Phase contrast magnetic resonance
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Ingeniería Electrónica
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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In patients at risk of intraventrcular thrombosis, the benefits of chronic anticoagulation therapy need to be balanced with the pro-hemorrhagic effects of therapy. Blood stasis in the cardiac chambers is a recognized risk factor for intracardiac thrombosis and potential cardiogenic embolic events. In this work, we present a novel flow image-based method to assess the location and extent of intraventricular stasis regions inside the left ventricle (LV) by digital processing flow-velocity images obtained either by phase-contrast magnetic resonance (PCMR) or 2D color-Doppler velocimetry (echo-CDV). This approach is based on quantifying the distribution of the blood Residence Time (TR) from time-resolved blood velocity fields in the LV. We tested the new method in illustrative examples of normal hearts, patients with dilated cardiomyopathy and one patient before and after the implantation of a left ventricular assist device (LVAD). The method allowed us to assess in-vivo the location and extent of the stasis regions in the LV. Original metrics were developed to integrate flow properties into simple scalars suitable for a robust and personalized assessment of the risk of thrombosis. From a clinical perspective, this work introduces the new paradigm that quantitative flow dynamics can provide the basis to obtain subclinical markers of intraventricular thrombosis risk. The early prediction of LV blood stasis may result in decrease strokes by appropriate use of anticoagulant therapy for the purpose of primary and secondary prevention. It may also have a significant impact on LVAD device design and operation set-up.

Funding Projects

Government of SpainPI12/02885UnspecifiedUnspecifiedUnspecified
Government of SpainPIS09/02603UnspecifiedUnspecifiedUnspecified
Government of SpainRD12/0042UnspecifiedUnspecifiedUnspecified
Government of SpainCM12/00273UnspecifiedUnspecifiedUnspecified

More information

Item ID: 46264
DC Identifier: http://oa.upm.es/46264/
OAI Identifier: oai:oa.upm.es:46264
DOI: 10.1016/j.jbiomech.2015.11.049
Official URL: http://www.sciencedirect.com/science/article/pii/S0021929015006910
Deposited by: Memoria Investigacion
Deposited on: 06 Jun 2017 15:04
Last Modified: 04 Apr 2019 08:56
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