A clinical method for mapping and quantifying blood stasis in the left ventricle

Rossini, Lorenzo; Martínez Legazpi, Pablo; Vu, Vi; Fernández Friera, Leticia; Pérez del Villar Moro, Candelas; Rodríguez López, Sara; Benito Mate, Yolanda; Borja, María Guadalupe; Pastor Escuredo, David; Yotti, Raquel; Ledesma Carbayo, Maria Jesus; Kahn, Andrew M.; Ibañez, Borja; Fernández Avilés, Francisco; Newman, Karen May; Bermejo Parra, Javier y Álamo de Pedro, Juan Carlos del (2016). A clinical method for mapping and quantifying blood stasis in the left ventricle. "Journal of biomechanics", v. 49 (n. 11); pp. 2152-2161. ISSN 0021-9290. https://doi.org/10.1016/j.jbiomech.2015.11.049.


Título: A clinical method for mapping and quantifying blood stasis in the left ventricle
  • Rossini, Lorenzo
  • Martínez Legazpi, Pablo
  • Vu, Vi
  • Fernández Friera, Leticia
  • Pérez del Villar Moro, Candelas
  • Rodríguez López, Sara
  • Benito Mate, Yolanda
  • Borja, María Guadalupe
  • Pastor Escuredo, David
  • Yotti, Raquel
  • Ledesma Carbayo, Maria Jesus
  • Kahn, Andrew M.
  • Ibañez, Borja
  • Fernández Avilés, Francisco
  • Newman, Karen May
  • Bermejo Parra, Javier
  • Álamo de Pedro, Juan Carlos del
Tipo de Documento: Artículo
Título de Revista/Publicación: Journal of biomechanics
Fecha: 7 Noviembre 2016
Volumen: 49
Palabras Clave Informales: Blood stasis; Residence time; Intraventricular thrombosis; Left ventricular assist devices; Echocardiography; Phase contrast magnetic resonance
Escuela: E.T.S.I. Telecomunicación (UPM)
Departamento: Ingeniería Electrónica
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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In patients at risk of intraventrcular thrombosis, the benefits of chronic anticoagulation therapy need to be balanced with the pro-hemorrhagic effects of therapy. Blood stasis in the cardiac chambers is a recognized risk factor for intracardiac thrombosis and potential cardiogenic embolic events. In this work, we present a novel flow image-based method to assess the location and extent of intraventricular stasis regions inside the left ventricle (LV) by digital processing flow-velocity images obtained either by phase-contrast magnetic resonance (PCMR) or 2D color-Doppler velocimetry (echo-CDV). This approach is based on quantifying the distribution of the blood Residence Time (TR) from time-resolved blood velocity fields in the LV. We tested the new method in illustrative examples of normal hearts, patients with dilated cardiomyopathy and one patient before and after the implantation of a left ventricular assist device (LVAD). The method allowed us to assess in-vivo the location and extent of the stasis regions in the LV. Original metrics were developed to integrate flow properties into simple scalars suitable for a robust and personalized assessment of the risk of thrombosis. From a clinical perspective, this work introduces the new paradigm that quantitative flow dynamics can provide the basis to obtain subclinical markers of intraventricular thrombosis risk. The early prediction of LV blood stasis may result in decrease strokes by appropriate use of anticoagulant therapy for the purpose of primary and secondary prevention. It may also have a significant impact on LVAD device design and operation set-up.

Proyectos asociados

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Gobierno de EspañaCM12/00273Sin especificarSin especificarSin especificar
Horizonte 20201R21HL108268-01Sin especificarSin especificarSin especificar
Horizonte 202014GRNT20530004Sin especificarSin especificarSin especificar

Más información

ID de Registro: 46264
Identificador DC: http://oa.upm.es/46264/
Identificador OAI: oai:oa.upm.es:46264
Identificador DOI: 10.1016/j.jbiomech.2015.11.049
URL Oficial: http://www.sciencedirect.com/science/article/pii/S0021929015006910
Depositado por: Memoria Investigacion
Depositado el: 06 Jun 2017 15:04
Ultima Modificación: 06 Jun 2017 15:04
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