Development of a versatile procedure for the biofunctionalization of Ti-6Al-4V implants

Rezvanian, Parsa and Arroyo Hernández, María and Ramos Gómez, Milagros and Daza García, Rafael and Elices Calafat, Manuel and Guinea Tortuero, Gustavo Víctor and Pérez Rigueiro, José (2016). Development of a versatile procedure for the biofunctionalization of Ti-6Al-4V implants. "Applied Surface Science", v. 387 ; pp. 652-660. ISSN 0169-4332. https://doi.org/10.1016/j.apsusc.2016.06.139.

Description

Title: Development of a versatile procedure for the biofunctionalization of Ti-6Al-4V implants
Author/s:
  • Rezvanian, Parsa
  • Arroyo Hernández, María
  • Ramos Gómez, Milagros
  • Daza García, Rafael
  • Elices Calafat, Manuel
  • Guinea Tortuero, Gustavo Víctor
  • Pérez Rigueiro, José
Item Type: Article
Título de Revista/Publicación: Applied Surface Science
Date: November 2016
ISSN: 0169-4332
Volume: 387
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Titanium (Ti) and titanium alloys are among the most-commonly used metallic materials for implantation in the human body for the purpose of replacing hard tissue. Although Ti and its alloys are widely used for such an aim, in implants of a long duration they exhibit some shortcomings due to the loosening of the very implant. This phenomenon is highly dependent on the interaction between the organic tissues and the surface of the implant. In this study, the authors introduce a surface treatment technique for functionalization of the surface of Ti-6Al-4V alloy with amino groups that could help to control this interaction. The functionalized layer was deposited by activated vapor silanization (AVS), which has been proven as a reliable and robust technique with other materials. The resulting biofunctional layers were characterized by atomic force microscopy and fluorescence microscopy, with the optimal conditions for the deposition of a homogeneous film with a high density of amino groups being determined. Additionally, the non-toxic nature and stability of the biofunctional layer were confirmed by cell culturing. The results show the formation of a homogeneous biofunctional amine layer on Ti-6Al-4V alloy that may be used as a platform for the subsequent covalent immobilization of proteins or other biomolecules.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainMAT2012-38412-C02-01UnspecifiedUniversidad Politécnica de MadridDesarrollo de biomateriales basados en la seda para aplicaciones en medicina regenerativa e ingeniería de tejidos
Government of SpainDPI2013-46485UnspecifiedUnspecifiedUnspecified
Madrid Regional GovernmentS2011/BMD-2460NEUROTECUnspecifiedPrograma integral de ingeniería biomédica para el desarrollo de técnicas diagnósticas y terapeúticas en enfermedades neurológicas

More information

Item ID: 47995
DC Identifier: http://oa.upm.es/47995/
OAI Identifier: oai:oa.upm.es:47995
DOI: 10.1016/j.apsusc.2016.06.139
Official URL: http://www.sciencedirect.com/science/article/pii/S016943321631368X
Deposited by: Memoria Investigacion
Deposited on: 12 Dec 2018 08:05
Last Modified: 12 Dec 2018 08:06
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