Mechanical behavior of bilayered small-diameter nanofibrous structures as biomimetic vascular grafts

Montini Ballarin, Florencia and Calvo Aguilar, Daniel and Caracciolo, Pablo C. and Rojo Pérez, Francisco Javier and Frontini, Patricia M. and Abraham, Gustavo A. and Guinea Tortuero, Gustavo V. (2016). Mechanical behavior of bilayered small-diameter nanofibrous structures as biomimetic vascular grafts. "Journal of the Mechanical Behavior of Biomedical Materials", v. 60 ; pp. 220-233. ISSN 1751-6161. https://doi.org/10.1016/j.jmbbm.2016.01.025.

Description

Title: Mechanical behavior of bilayered small-diameter nanofibrous structures as biomimetic vascular grafts
Author/s:
  • Montini Ballarin, Florencia
  • Calvo Aguilar, Daniel
  • Caracciolo, Pablo C.
  • Rojo Pérez, Francisco Javier
  • Frontini, Patricia M.
  • Abraham, Gustavo A.
  • Guinea Tortuero, Gustavo V.
Item Type: Article
Título de Revista/Publicación: Journal of the Mechanical Behavior of Biomedical Materials
Date: July 2016
ISSN: 1751-6161
Volume: 60
Subjects:
Freetext Keywords: Electrospinning; Small-diameter vascular grafts; Dynamic compliance; Biomimetic behavior
Faculty: E.T.S.I. Caminos, Canales y Puertos (UPM)
Department: Ciencia de los Materiales
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

To these days, the production of a small diameter vascular graft (<6 mm) with an appropriate and permanent response is still challenging. The mismatch in the grafts mechanical properties is one of the principal causes of failure, therefore their complete mechanical characterization is fundamental. In this work the mechanical response of electrospun bilayered small-diameter vascular grafts made of two different bioresorbable synthetic polymers, segmented poly (ester urethane) and poly (L-lactic acid), that mimic the biomechanical characteristics of elastin and collagen is investigated. AJ-shaped response when subjected to internal pressure was observed as a cause of the nanofibrous layered structure, and the materials used. Compliance values were in the order of natural coronary arteries and very close to the bypass gold standard-saphenous vein. The suture retention strength and burst pressure values were also in the range of natural vessels. Therefore, the bilayered vascular grafts presented here are very promising for future application as small-diameter vessel replacements.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainMAT2012-36096EDDUCOPROFrancisco Javier Rojo PérezEstudio dinámico de la durabilidad de biomateriales de colágeno para prótesis valvulares
Government of SpainMAT2012-38412-C02-01BIOSILKJosé Pérez RigueiroDesarrollo de biomateriales basados en la seda para aplicaciones en medicina regenerativa e ingeniería de tejidos
Madrid Regional GovernmentS2011/BMD-2460NEUROTECFrancisco del Pozo GuerreroPrograma integral de ingeniería biomédica para el desarrollo de técnicas diagnósticas y terapeúticas en enfermedades neurológicas

More information

Item ID: 48092
DC Identifier: http://oa.upm.es/48092/
OAI Identifier: oai:oa.upm.es:48092
DOI: 10.1016/j.jmbbm.2016.01.025
Official URL: http://www.sciencedirect.com/science/article/pii/S175161611600028X
Deposited by: Memoria Investigacion
Deposited on: 19 Oct 2017 14:53
Last Modified: 02 Feb 2018 23:30
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