A diet supplemented with n-3 polyunsaturated fatty acids influences the metabolic and endocrine response of rabbit does and their offspring

Rodríguez Francisco, María; García García, R. M.; Arias Álvarez, María; Formoso Rafferty, Nora; Millán, P.; López Tello, J.; Lorenzo, P.L.; González Bulnes, Antonio y García Rebollar, Pilar (2017). A diet supplemented with n-3 polyunsaturated fatty acids influences the metabolic and endocrine response of rabbit does and their offspring. "Journal of Animal Science", v. 95 (n. 6); pp. 2690-2700. ISSN 0021-8812. https://doi.org/10.2527/jas.2017.1429.

Descripción

Título: A diet supplemented with n-3 polyunsaturated fatty acids influences the metabolic and endocrine response of rabbit does and their offspring
Autor/es:
  • Rodríguez Francisco, María
  • García García, R. M.
  • Arias Álvarez, María
  • Formoso Rafferty, Nora
  • Millán, P.
  • López Tello, J.
  • Lorenzo, P.L.
  • González Bulnes, Antonio
  • García Rebollar, Pilar
Tipo de Documento: Artículo
Título de Revista/Publicación: Journal of Animal Science
Fecha: Junio 2017
Volumen: 95
Materias:
Palabras Clave Informales: docosahexaenoic acid, eicosapentaenoic acid, leptin, lipid profile, metabolism, oxidative stress
Escuela: E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Departamento: Otro
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

The aim of the present study was to evaluate the productive, endocrine, and metabolic responses as well as oxidative stress of rabbit does and their offspring when fed a diet supplemented with n -3 PUFA during their first productive cycle. To this aim, a total of 105 rabbit does were fed ad libitum from d 60 to 172 of age 2 isoenergetic and isoproteic diets dif - fering in fatty acid composition. The control diet ( n = 52 does) contained 45.9 g/kg of n -3 of the total fatty acids and the enriched diet ( n = 53 does) contained 149.2 g/kg of n -3 of the total fatty acids. Both experi - mental groups had similar feed intake during rearing, pregnancy, and lactation. The enrichment of diet had no effect on ultrasonographic assessment of does on d 9 and 16 of pregnancy, with an embryonic vesicle number and fetus and placenta size similar between groups ( P > 0.05). Even though there were no major effects ( P > 0.05) on fertility, duration of gestation, and number born alive and stillborn kits at parturition, live kits from enriched does were longer (71.6 ± 2.42 vs. 79.5 ± 2.13 mm; P < 0.05) and tended to be heavier (42.5 ± 3.94 vs. 50.8 ± 3.47 g; P = 0.07) than those from control does ( P < 0.05). The 2 groups had similar milk production and mortality values during lacta - tion; consequently, there were no differences between diets in ADG, litter weight, and number of weaned kits ( P > 0.05). In enriched does, higher plasma leptin and estradiol concentrations than in control does ( P < 0.05) were observed. In addition, enriched females also had lower total and high-density lipoprotein cho - lesterol (HDL-c) than control females during lactation ( P < 0.05). Regarding offspring, the enrichment of diet with PUFA caused a hyperlipidemic status (greater values of plasma triglycerides, total cholesterol, and HDL-c; P < 0.05) at 1 d postpartum (dpp), compared with the control group, that disappeared at 32 dpp. Supplemented does before parturition and their off - spring at 1 dpp had greater oxidative stress than those in the control group. In conclusion, an increase of n -3 PUFA concentration in the diet of rabbit does and, consequently, of their offspring during a productive cycle alters their lipid profile and the indicators of oxi - dative stress, without major endocrine modifications or improvements in the productive variables.

Más información

ID de Registro: 50033
Identificador DC: http://oa.upm.es/50033/
Identificador OAI: oai:oa.upm.es:50033
Identificador DOI: 10.2527/jas.2017.1429
URL Oficial: https://academic.oup.com/jas/article/95/6/2690/4702599
Depositado por: Memoria Investigacion
Depositado el: 12 Abr 2018 09:00
Ultima Modificación: 12 Abr 2018 09:00
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