How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid

López Hernández, Ana and Casquel Del Campo, Rafael and Holgado Bolaños, Miguel and Cornago, Iñaki and Fernández, Fátima and Ciaurriz, Paula and Sanza Gutiérrez, Francisco Javier and Santamaría Fernández, Beatriz and Maigler, M. Victoria and Quintero Moreno, Sergio Andrés and Laguna Heras, Maria Fe (2018). How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid. "Sensors and Actuators B: Chemical", v. 259 ; pp. 956-962. ISSN 0925-4005. https://doi.org/10.1016/j.snb.2017.11.029.

Description

Title: How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid
Author/s:
  • López Hernández, Ana
  • Casquel Del Campo, Rafael
  • Holgado Bolaños, Miguel
  • Cornago, Iñaki
  • Fernández, Fátima
  • Ciaurriz, Paula
  • Sanza Gutiérrez, Francisco Javier
  • Santamaría Fernández, Beatriz
  • Maigler, M. Victoria
  • Quintero Moreno, Sergio Andrés
  • Laguna Heras, Maria Fe
Item Type: Article
Título de Revista/Publicación: Sensors and Actuators B: Chemical
Date: 15 April 2018
Volume: 259
Subjects:
Freetext Keywords: Biosensing enhance between dry/wet conditions; Optical biosensor; Resonant nanopillars; In-situ diagnosis; Vertical optical interrogation; Label-free
Faculty: E.T.S.I. Industriales (UPM)
Department: Física Aplicada e Ingeniería de Materiales
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

In this work we demonstrate the advantage of performing the biosensing process of a refractive indexoptical biosensor under dry conditions, in comparison with the biosensing structure immersed in fluid.We developed a biosensing experiment over a specific transducer based on resonant nanopillars (R-NPs)arrays. The optical interrogation to monitor the recognition events was firstly performed with the R-NPsin dry, only in contact with the air, and secondly with the R-NPs immersed in water. We observed asignificant enhance in the sensitivity of the biosensing curve response for the R-NPs in dry conditions,leading an improvement of the Limit of Detection (LoD) in more than one order of magnitude. These resultsare also in good correlation with 3D-Finite difference time domain simulations carried out for both fluidconditions. According to this result, any interferometric optical bio-transducer for in-situ diagnosis willimprove the sensitivity in case it can operate in dry conditions. Moreover, measuring in simple drops ofbiological samples, in dry conditions, will be a relevant issue for Point of Care Devices

Funding Projects

TypeCodeAcronymLeaderTitle
FP7614057EnviguardUnspecifiedOCEAN 2013.1 - Biosensors for real time monitoring of biohazard and man made chemical contaminants in the marine environment
Government of SpainTEC2012-31145PLATONUnspecifiedBIOCHIP KITS BASADOS EN CELDAS BIOFOTONICAS Y PLATAFORMAS AVANZADAS DE INTERROGACION OPTICA
Government of SpainRTC-2015-3273-1ATAPOCUnspecifiedDesarrollo y validación clínica de un dispositivo para el diagnóstico y seguimiento de las alergias y tolerancias alimentarias

More information

Item ID: 50264
DC Identifier: http://oa.upm.es/50264/
OAI Identifier: oai:oa.upm.es:50264
DOI: 10.1016/j.snb.2017.11.029
Official URL: https://www.sciencedirect.com/science/article/pii/S0925400517321603?via%3Dihub
Deposited by: Memoria Investigacion
Deposited on: 13 Jun 2018 16:55
Last Modified: 13 Jun 2018 16:55
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