Leishmania donovani: thionins, plant antimicrobial peptides with leishmanicidal activity

Berrocal Lobo, Marta and Molina Fernández, Antonio and Rodriguez Palenzuela, Pablo and García Olmedo, Francisco and Rivas, Luis (2009). Leishmania donovani: thionins, plant antimicrobial peptides with leishmanicidal activity. "Experimental Parasitology", v. 122 (n. 3); pp. 247-249. ISSN 0014-4894. https://doi.org/10.1016/j.exppara.2009.03.019.

Description

Title: Leishmania donovani: thionins, plant antimicrobial peptides with leishmanicidal activity
Author/s:
  • Berrocal Lobo, Marta
  • Molina Fernández, Antonio
  • Rodriguez Palenzuela, Pablo
  • García Olmedo, Francisco
  • Rivas, Luis
Item Type: Article
Título de Revista/Publicación: Experimental Parasitology
Date: July 2009
ISSN: 0014-4894
Volume: 122
Subjects:
Faculty: E.T.S.I. Montes (UPM)
Department: Biotecnologia [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The leishmanicidal activity of plant antibiotic peptides (PAPs) from the principal families, such wheat thionins, a barley lipid transfer protein and potato defensins and snakins were tested in vitro against Leishmania donovani. Only thionins and defensins were active against this human pathogen at a low micromolar range of concentrations. Thionins resulted as the most active peptides tested until now. They collapsed ionic and pH gradients across the parasite plasma membrane together with a rapid depletion of intracellular ATP without affecting mitochondrial potential. Hence the lethal effect of thionins was mostly associated to permeabilization of the plasma membrane leading to an immediate death of the parasite. The present work is the first evidence for leishmanicidal activity in plant peptides. Future prospects for their development as new antiparasite agents on human diseases are considered

More information

Item ID: 5066
DC Identifier: http://oa.upm.es/5066/
OAI Identifier: oai:oa.upm.es:5066
DOI: 10.1016/j.exppara.2009.03.019
Official URL: http://www.sciencedirect.com/science/journal/00144894
Deposited by: Memoria Investigacion
Deposited on: 25 Nov 2010 09:29
Last Modified: 20 Apr 2016 14:02
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