Neural control of blood pressure in women: differences according to age

Peinado Lozano, Ana Belen and Harvey, Ronee E. and Hart, Emma C. and Charkoudian, Nisha and Curry, Timothy B. and Nicholson, Wayne T. and Wallin, B. Gunnar and Joyner, Michael J. and Barnes, Jill N. (2017). Neural control of blood pressure in women: differences according to age. "Clinical Automatic Research", v. 27 (n. 3); pp. 157-165. ISSN 0959-9851. https://doi.org/10.1007/s10286-017-0403-0.

Description

Title: Neural control of blood pressure in women: differences according to age
Author/s:
  • Peinado Lozano, Ana Belen
  • Harvey, Ronee E.
  • Hart, Emma C.
  • Charkoudian, Nisha
  • Curry, Timothy B.
  • Nicholson, Wayne T.
  • Wallin, B. Gunnar
  • Joyner, Michael J.
  • Barnes, Jill N.
Item Type: Article
Título de Revista/Publicación: Clinical Automatic Research
Date: June 2017
ISSN: 0959-9851
Volume: 27
Subjects:
Freetext Keywords: Aging; Baroreflex function; Menopause; Sympathetic nerve activity
Faculty: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Department: Salud y Rendimiento Humano
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Purpose The blood pressure ‘error signal’ represents the difference between an individual’s mean diastolic blood pressure and the diastolic blood pressure at which 50% of cardiac cycles are associated with a muscle sympathetic nerve activity burst (the ‘‘T50’’). In this study we evaluated whether T50 and the error signal related to the extent of change in blood pressure during autonomic blockade in young and older women, to study potential differences in sympathetic neural mechanisms regulating blood pressure before and after menopause. Methods We measured muscle sympathetic nerve activity and blood pressure in 12 premenopausal (25 ± 1 years) and 12 postmenopausal women (61 ± 2 years) before and during complete autonomic blockade with trimethaphan camsylate. Results At baseline, young women had a negative error signal (-8 ± 1 versus 2 ± 1 mmHg, p\0.001; respectively) and lower muscle sympathetic nerve activity (15 ± 1 versus 33 ± 3 bursts/min, p\0.001; respectively) than older women. The change in diastolic blood pressure after autonomic blockade was associated with baseline T50 in older women (r = -0.725, p = 0.008) but not in young women (r = -0.337, p = 0.29). Women with the most negative error signal had the lowest muscle sympathetic nerve activity in both groups (young: r = 0.886, p\0.001; older: r = 0.870, p\0.001). Conclusions Our results suggest that there are differences in baroreflex control of muscle sympathetic nerve activity between young and older women, using the T50 and error signal analysis. This approach provides further information on autonomic control of blood pressure in women.

More information

Item ID: 50697
DC Identifier: http://oa.upm.es/50697/
OAI Identifier: oai:oa.upm.es:50697
DOI: 10.1007/s10286-017-0403-0
Official URL: https://link.springer.com/article/10.1007/s10286-017-0403-0
Deposited by: Memoria Investigacion
Deposited on: 24 Oct 2018 13:10
Last Modified: 12 Nov 2018 11:54
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