Cell Mechanosensors and the Possibilities of Using Magnetic Nanoparticles to Study Them and to Modify Cell Fate

Shen, Yajing and Cheng, Yu and Uyeda, Taro Q. P. and Plaza Baonza, Gustavo Ramón (2017). Cell Mechanosensors and the Possibilities of Using Magnetic Nanoparticles to Study Them and to Modify Cell Fate. "Annals of Biomedical Engineering", v. 45 (n. 10); pp. 2475-2486. ISSN 1573-9686. https://doi.org/10.1007/s10439-017-1884-7.

Description

Title: Cell Mechanosensors and the Possibilities of Using Magnetic Nanoparticles to Study Them and to Modify Cell Fate
Author/s:
  • Shen, Yajing
  • Cheng, Yu
  • Uyeda, Taro Q. P.
  • Plaza Baonza, Gustavo Ramón
Item Type: Article
Título de Revista/Publicación: Annals of Biomedical Engineering
Date: 25 July 2017
ISSN: 1573-9686
Volume: 45
Subjects:
Freetext Keywords: Mechanotransduction, Signaling Cascade, Cytoskeleton, Magnetic Nanoparticles, Rotating Magnetic Field, Functionalization, Organelle Targeting, Localized Stimulation, Cell Differentiation
Faculty: E.T.S.I. Caminos, Canales y Puertos (UPM)
Department: Ciencia de los Materiales
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The use of magnetic nanoparticles (MNPs) is a promising technique for future advances in biomedical applications. This idea is supported by the availability of MNPs that can target specific cell components, the variety of shapes of MNPs and the possibility of finely controlling the applied magnetic forces. To examine this opportunity, here we review the current developments in the use of MNPs to mechanically stimulate cells and, specifically, the cell mechanotransduction systems. We analyze the cell components that may act as mechanosensors and their effect on cell fate and we focus on the promising possibilities of controlling stem-cell differentiation, inducing cancer-cell death and treating nervous-system diseases.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainMAT2016-76847-RMINECOUnspecifiedDeformabilidad de linfocitos T como biomarcador mecánico de inmunosenescencia y desarrollo de tecnología para su aplicación clínica

More information

Item ID: 52686
DC Identifier: http://oa.upm.es/52686/
OAI Identifier: oai:oa.upm.es:52686
DOI: 10.1007/s10439-017-1884-7
Official URL: https://link.springer.com/article/10.1007%2Fs10439-017-1884-7
Deposited by: Memoria Investigacion
Deposited on: 19 Oct 2018 11:02
Last Modified: 19 Oct 2018 11:02
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